ID F6UEN5_CALJA Unreviewed; 476 AA.
AC F6UEN5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=D(1B) dopamine receptor {ECO:0000256|ARBA:ARBA00018627};
DE AltName: Full=D(5) dopamine receptor {ECO:0000256|ARBA:ARBA00042808};
DE AltName: Full=Dopamine D5 receptor {ECO:0000256|ARBA:ARBA00041538};
GN Name=DRD5 {ECO:0000313|Ensembl:ENSCJAP00000042994.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000042994.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000042994.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000042994.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC which activate adenylyl cyclase. {ECO:0000256|ARBA:ARBA00002363}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_002746038.1; XM_002745992.3.
DR AlphaFoldDB; F6UEN5; -.
DR STRING; 9483.ENSCJAP00000042994; -.
DR Ensembl; ENSCJAT00000000186.4; ENSCJAP00000042994.1; ENSCJAG00000000106.4.
DR GeneID; 100408128; -.
DR KEGG; cjc:100408128; -.
DR CTD; 1816; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000157037; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; F6UEN5; -.
DR OMA; HWHRDKA; -.
DR OrthoDB; 2900736at2759; -.
DR TreeFam; TF325181; -.
DR Proteomes; UP000008225; Chromosome 3.
DR Bgee; ENSCJAG00000000106; Expressed in frontal cortex.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
DR GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
DR GO; GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0060292; P:long-term synaptic depression; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0001994; P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; IEA:Ensembl.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR GO; GO:0045924; P:regulation of female receptivity; IEA:Ensembl.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0046960; P:sensitization; IEA:Ensembl.
DR GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000497; Dopamine_D5_rcpt.
DR InterPro; IPR000929; Dopamine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF136; D(1B) DOPAMINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00566; DOPAMINED1BR.
DR PRINTS; PR00242; DOPAMINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..358
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 476 AA; 52470 MW; BD6088D68FA618BC CRC64;
MLPPGSNGTA YPGQFALNQQ LAQGNTVGGS AGAPPLGPAQ VVTAGLLTLL IIWTLLGNVL
VCAAIVRSRH LRAKMTNVFI VSLAVSDLFV ALLVMPWKAV AEVAGYWPFG AFCDVWVAFD
IMCSTASILN LCVISVDRYW AISRPFRYER KMTQRMALVM VGLAWTLSIL ISFIPVQLNW
HRDQAGSWGG LDLPNNLANG TPWEDVWEPD VRAENCDSSL NRTYAISSSL VSFYIPVAIM
IVTYTRIYRI AQVQIRRISS LERAAEHAQS CRSSAACAPE TSLRASIKKE TKVLKTLSVI
MGVFVCCWLP FFVLNCMVPF CSGHPEGPPA GFPCVSETTF DVFVWFGWAN SSLNPIIYAF
NADFRKVFAQ LLGCSHLCSR TPVEMVNISN ELVSYNQDTV FQKEITAAYI HMMPNAVTPG
DPQVDDDEEE GSFDRMSQIY QMSPDGDPVA ESVWELDCEG EISLGKITPF TPNGFH
//
