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Database: UniProt
Entry: F6UFE6_HORSE
LinkDB: F6UFE6_HORSE
Original site: F6UFE6_HORSE 
ID   F6UFE6_HORSE            Unreviewed;       757 AA.
AC   F6UFE6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 4.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator like 1 {ECO:0000313|Ensembl:ENSECAP00000018166.4};
GN   Name=RGL1 {ECO:0000313|Ensembl:ENSECAP00000018166.4,
GN   ECO:0000313|VGNC:VGNC:22334};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018166.4, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000018166.4, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018166.4,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000018166.4}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018166.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; F6UFE6; -.
DR   Ensembl; ENSECAT00000022005.4; ENSECAP00000018166.4; ENSECAG00000020299.4.
DR   CTD; 23179; -.
DR   VGNC; VGNC:22334; RGL1.
DR   GeneTree; ENSGT00940000156012; -.
DR   HOGENOM; CLU_010252_0_1_1; -.
DR   TreeFam; TF315204; -.
DR   Proteomes; UP000002281; Chromosome 5.
DR   Bgee; ENSECAG00000020299; Expressed in synovial membrane of synovial joint and 21 other cell types or tissues.
DR   ExpressionAtlas; F6UFE6; baseline.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17210; RA_RGL; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030748; RGL1_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          65..196
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          232..499
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          637..724
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          521..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  85300 MW;  DB3CDF3EF5185940 CRC64;
     MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD QLPPGHTVSQ
     YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY RGFASTKEVL ELLLDRYGNL
     TSPNCEEDGR QSSSESKTVI RNAIASILRA WLDQCAEDFR EPPHFPCLQK LLDYLKRMMP
     GSDPERRAQN LLEQFHKQEV ETDNGFPNTM SFSLEEEEEL EGGGSAEFTC FSEDLVAEQL
     TYMDAQLFKK VVPHHCLGCI WSRRDKKENK HLAPTIRATI SQFNALTKCV VSTILGGKEL
     KTQQRAKIIE KWINIAHECR ILKNFSSLRA IVSALQSNSI YRLKKTWAAV PKDRMLMFEE
     LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT QRRLQLQKDM GVMQGTVPYL
     GTFLTDLTML DTALQDYIEE FEVIAQIKLL QSACNSYCMT PDQKFIQWFQ RQQLLTEEES
     YALSCEIEAA ADASATSPKP RKSMVKRLSL LFLGSDIITS STPTKEQPKS TASGSSGESM
     DSVSVSSCES NHSEAEEGSL TPMDTPDDPQ KKLSESSSSC SSIHSMDTTS SGMSSLINPL
     SSPPSCNNNP KIHKRSVSVT SITSTVLPPV YNQQNEDTCI IRISVEDNNG NMYKSIMLTS
     QDKTPAVIQR AMLKHNLESD PAEEYELVQV ISEDKELVIP DSANVFYAMN SQVNFDFILR
     KKNSMEEQVK LRSRTSLTLP RTAKRGCWSN RHSKITL
//
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