GenomeNet

Database: UniProt
Entry: F6UIU1_CALJA
LinkDB: F6UIU1_CALJA
Original site: F6UIU1_CALJA 
ID   F6UIU1_CALJA            Unreviewed;       866 AA.
AC   F6UIU1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSCJAP00000028281.3};
GN   Name=PMS2 {ECO:0000313|Ensembl:ENSCJAP00000028281.3};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028281.3, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000028281.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000028281.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F6UIU1; -.
DR   STRING; 9483.ENSCJAP00000028281; -.
DR   Ensembl; ENSCJAT00000029886.5; ENSCJAP00000028281.3; ENSCJAG00000015340.5.
DR   eggNOG; KOG1978; Eukaryota.
DR   GeneTree; ENSGT00940000155381; -.
DR   HOGENOM; CLU_004131_0_2_1; -.
DR   InParanoid; F6UIU1; -.
DR   OMA; HIPRPSK; -.
DR   OrthoDB; 4698638at2759; -.
DR   TreeFam; TF300711; -.
DR   Proteomes; UP000008225; Chromosome 2.
DR   Bgee; ENSCJAG00000015340; Expressed in frontal cortex and 6 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032389; C:MutLalpha complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR   GO; GO:0032138; F:single base insertion or deletion binding; IEA:Ensembl.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR   GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR   GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR   GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR   GO; GO:0016447; P:somatic recombination of immunoglobulin gene segments; IEA:Ensembl.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          231..368
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          682..826
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          396..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..444
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..502
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..549
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   866 AA;  96650 MW;  2EF19521B3EFB598 CRC64;
     MYLLVRPDGS CLTEPAKAIR PIDRKSVHQI CSGQVVLSLS TAVKELVENS LDAGATNIDL
     KLKDYGVDLI EVSDNGCGVE EENFEGLTLK HYTSKIQDFA DLTQVETFGF RGEALSSLCA
     LSDVTISTCH ASVKVGTRLV FDHSGKIIQK TPYPRPKGTT VSVQQLFYTL PVRHKEFQRN
     IKKEYAKMVQ VLHAYCIISS GIRVSCTNQL GQGKRQPVVC TGGSPSIKEN IGSVFGQKQL
     QSLIPFVQLP PSDSVCEEYG LSCSDALHNL FYISGFISQC AHGVGRSSTD RQFFFINRRP
     CDPAKVSRLV NEVYHMYNRN QYPFVVLNIS VDAECVDINV TPDKRQILLQ EEKLLLAVLK
     TSLIGMFDSD VNKLNVSQQP LLDIGGNLMK VHAADLEKPL PEQQDNSPSS RTREEKRDVS
     ISRLREAFSL HHTAESKSHS LKTPEPRRSS PGQKRGMPSF STSDAISDRG FLEPQKEVAS
     SSEGPSDPAD RAEVEKDSGH GSTSMDSEGF SIPDTGGYYS SKCVASSPED RGSQESVDSR
     EKVPETDNPF SDVDCRLNQE DTGCKFRVLP QPRNLASPNT KRFKKEEILS NSDIRQKLVN
     TQNVSASQVD VAVKIDKKVV PLDFSMSSLT KRMKQFHHKA KQSEGEQNYR KFRAKICPGE
     NQAAEDELRK EISKSMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK YNFEMLQQHT
     VLQGQRLIVP QTLNLTAVNE IILIENLEIF RKNGFDFVID ESAPVTQKAK LISLPTSKNW
     TFGPQDIDEL IFMLSDSPGV MCRPSRVKQM FASRACRKSV MIGTALNPSE MKKLITHMGE
     MDHPWNCPHG RPTMRHIANL GVISQN
//
DBGET integrated database retrieval system