ID F6UIU1_CALJA Unreviewed; 866 AA.
AC F6UIU1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSCJAP00000028281.3};
GN Name=PMS2 {ECO:0000313|Ensembl:ENSCJAP00000028281.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028281.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000028281.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000028281.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; F6UIU1; -.
DR STRING; 9483.ENSCJAP00000028281; -.
DR Ensembl; ENSCJAT00000029886.5; ENSCJAP00000028281.3; ENSCJAG00000015340.5.
DR eggNOG; KOG1978; Eukaryota.
DR GeneTree; ENSGT00940000155381; -.
DR HOGENOM; CLU_004131_0_2_1; -.
DR InParanoid; F6UIU1; -.
DR OMA; HIPRPSK; -.
DR OrthoDB; 4698638at2759; -.
DR TreeFam; TF300711; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000015340; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0032389; C:MutLalpha complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR GO; GO:0016447; P:somatic recombination of immunoglobulin gene segments; IEA:Ensembl.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 231..368
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 682..826
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 396..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 96650 MW; 2EF19521B3EFB598 CRC64;
MYLLVRPDGS CLTEPAKAIR PIDRKSVHQI CSGQVVLSLS TAVKELVENS LDAGATNIDL
KLKDYGVDLI EVSDNGCGVE EENFEGLTLK HYTSKIQDFA DLTQVETFGF RGEALSSLCA
LSDVTISTCH ASVKVGTRLV FDHSGKIIQK TPYPRPKGTT VSVQQLFYTL PVRHKEFQRN
IKKEYAKMVQ VLHAYCIISS GIRVSCTNQL GQGKRQPVVC TGGSPSIKEN IGSVFGQKQL
QSLIPFVQLP PSDSVCEEYG LSCSDALHNL FYISGFISQC AHGVGRSSTD RQFFFINRRP
CDPAKVSRLV NEVYHMYNRN QYPFVVLNIS VDAECVDINV TPDKRQILLQ EEKLLLAVLK
TSLIGMFDSD VNKLNVSQQP LLDIGGNLMK VHAADLEKPL PEQQDNSPSS RTREEKRDVS
ISRLREAFSL HHTAESKSHS LKTPEPRRSS PGQKRGMPSF STSDAISDRG FLEPQKEVAS
SSEGPSDPAD RAEVEKDSGH GSTSMDSEGF SIPDTGGYYS SKCVASSPED RGSQESVDSR
EKVPETDNPF SDVDCRLNQE DTGCKFRVLP QPRNLASPNT KRFKKEEILS NSDIRQKLVN
TQNVSASQVD VAVKIDKKVV PLDFSMSSLT KRMKQFHHKA KQSEGEQNYR KFRAKICPGE
NQAAEDELRK EISKSMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK YNFEMLQQHT
VLQGQRLIVP QTLNLTAVNE IILIENLEIF RKNGFDFVID ESAPVTQKAK LISLPTSKNW
TFGPQDIDEL IFMLSDSPGV MCRPSRVKQM FASRACRKSV MIGTALNPSE MKKLITHMGE
MDHPWNCPHG RPTMRHIANL GVISQN
//