ID F6UK30_ORNAN Unreviewed; 814 AA.
AC F6UK30;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022695.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000022695.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022695.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000022695.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022695.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6UK30; -.
DR STRING; 9258.ENSOANP00000022695; -.
DR Ensembl; ENSOANT00000022699.3; ENSOANP00000022695.2; ENSOANG00000014402.3.
DR eggNOG; KOG1225; Eukaryota.
DR GeneTree; ENSGT00940000155565; -.
DR HOGENOM; CLU_280282_0_0_1; -.
DR OMA; CISREEC; -.
DR TreeFam; TF329915; -.
DR Proteomes; UP000002279; Chromosome X5.
DR Bgee; ENSOANG00000014402; Expressed in fibroblast and 7 other cell types or tissues.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF3; TENASCIN-X; 1.
DR Pfam; PF07974; EGF_2; 5.
DR Pfam; PF18720; EGF_Tenascin; 8.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 594..684
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..737
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 85975 MW; 6351691D57FA1C6D CRC64;
MARNGPAPAE RQRVTLRTWP GPSPPRGNGS APAPRPPPRP GSRAGASAPQ LYEHTVEGGE
KQVVFTHRIN LPPGAGCGCP PGTEPPASGA EVRALQARLE ALEELVRGLR EQCAGGCCQP
GQTDVRTLCS LHGVFDLSRC GRCQCFPGYS GPACDHPACP GDCNRHGRCQ AGRCVCDPGY
SGDDCGARSC PGDCRGRGRC QDGRCVCRPG YTGEDCGSRA CPRGCSQRGR CQDGRCVCDP
GFAGDDCAQR GCPRDCSQRG RCQDGRCLCH PGYAGEDCAQ RTCPGDCSQR GLCRDGRCVC
DPGYAGEDCA QRSCPRDCSQ RGQCRDGSCV CDPGYAGEDC AQRSCPRDCS QRGQCRDGSC
VCDLGYEGED CAQRSCPRGC SQRGRCRDGR CVCHPGYAGE DCGTRTCPLG CRGRGRCRAG
VCVCDPGFTG EDCGTRSCPG DCRGRGRCED GRCVCWPGYA GEDCGSRSCP HDCRDHGRCR
DGRCVCDAGY TGEDCGSRSC PGDCNRRGLC RDGRCVCDPG YAGEDCGTQS CPHDCRGRGR
CQAGRCVCDP GYVGEDCGTR SCPGDCNRRG LCQDGRCVCE PGYSGRDSPP KRGPRGGLSV
TDETPDSLSL SWTVPEGRFD SFVVMYQDAD GRPQTVRVGG DQTEVTVSGL EPDRKYKLNL
FGLQGKQRVG PVSVATLLLA TRPDCKSPRS GCPVGFPPAL CPQPFPIPRG GRNPVNPGSP
NSPHPFPHVP PPSLPRPHAR HRALSPAAAA SQLLPFLSPT AKSPGQPLVT SCLGYCCLSF
PGPPLNCHLA KSSGQNRKAS VKSPSPGLSR SKAG
//
