ID F6UT65_HORSE Unreviewed; 789 AA.
AC F6UT65;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Family with sequence similarity 171 member B {ECO:0000313|Ensembl:ENSECAP00000020901.3};
GN Name=FAM171B {ECO:0000313|Ensembl:ENSECAP00000020901.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020901.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020901.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020901.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020901.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020901.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the FAM171 family.
CC {ECO:0000256|ARBA:ARBA00006818}.
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DR Ensembl; ENSECAT00000025135.4; ENSECAP00000020901.3; ENSECAG00000058607.1.
DR GeneTree; ENSGT00950000183184; -.
DR HOGENOM; CLU_004111_4_0_1; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000021377; Expressed in brainstem and 23 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018890; FAM171.
DR InterPro; IPR049175; FAM171_C.
DR InterPro; IPR048530; FAM171_N.
DR PANTHER; PTHR31626:SF2; PROTEIN FAM171B; 1.
DR PANTHER; PTHR31626; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20771; FAM171A1-2-B_C; 1.
DR Pfam; PF10577; FAM171A1-2-B_N; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..789
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040310881"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..294
FT /note="FAM171 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10577"
FT DOMAIN 555..787
FT /note="FAM171 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20771"
FT REGION 45..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 87573 MW; 0C7AA483FDD09230 CRC64;
MARLSRRVPC TLLFGLAAVL LKAQLVPAAA RAELSRSDLS LIQQQQQQQQ RQREEAEEER
PEVPGASSTV TVPVSVFMLK VQVNDIISRQ SLSQAVVEVF VNYTKTNSTV TKSNGAVLIK
VPYKLGLSLT IIAYKDGYVL TPLPWKTGRM PNAKSQPSVQ FSKALIKLPD SHHINNVTGY
LTVLQQFLKV DNFLYTTGIT LNKSGFESIE LTPLAAICVK IYSGGKELKV DGSIQVSLPL
LHTSDVSAGD HVPAWTFDMN TGAWINHGQG MVKEYNSHLV WTYDAPHLGY WIAAPLPGTR
GSGINGDSKN ITAYHTVFLT AILGGTIVIV IGFFAVLLCY CRDKCGTPQK RERNITKLEV
LKRDQTTSTT HINHISSVKV ALKAEDKSQL FNAKNSSYSP QKKEPSKAEA EERVSMVKTR
DNFKIYSEDV SFLSVNQNNY SRNPPQSLEP NVGSKQPKHI NNNLSSSLGD AQEEKRYLTG
NEEVYGRSHI PEQLMHIYSQ PIAILQTSDL FSTPEQLHTA KSATLPRKGQ LVYGQLMEPV
NRENFTQTLP KMPMHSHAQP PDAREENIPL EGQQSLPSQT SDWSRYSNSL LESVSVPGTL
NEAVVMTPFS SELQGISEQT LLELSKGKPS PHPRAWFVSL DGKPVAQVRH SFIDLKKGKR
TQSNDTSLDS GVDMNEHHSS RKLEREKTFI KSMHQPKILY LEDLDLSSSE SGTTVCSPED
PALRHILDGG SGAIMEHPGE ESPGRKSTVE DFEANTSPTK KRGRPPLAKR DSKTNIWKKR
EERPLIPIN
//
