ID F6UW47_ORNAN Unreviewed; 750 AA.
AC F6UW47;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Arylsulfatase D {ECO:0000313|Ensembl:ENSOANP00000006404.4};
GN Name=ARSD {ECO:0000313|Ensembl:ENSOANP00000006404.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000006404.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000006404.4, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000006404.4,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000006404.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000006404.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR AlphaFoldDB; F6UW47; -.
DR STRING; 9258.ENSOANP00000006404; -.
DR Ensembl; ENSOANT00000006406.4; ENSOANP00000006404.4; ENSOANG00000004038.4.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000161140; -.
DR HOGENOM; CLU_006332_13_4_1; -.
DR InParanoid; F6UW47; -.
DR OMA; HWNCIMM; -.
DR OrthoDB; 2913702at2759; -.
DR TreeFam; TF314186; -.
DR Proteomes; UP000002279; Chromosome 15.
DR Bgee; ENSOANG00000004038; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004065; F:arylsulfatase activity; IBA:GO_Central.
DR CDD; cd16159; ES; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 1.10.287.550; Helix hairpin bin; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693:SF12; ARYLSULFATASE D; 1.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR Pfam; PF14707; Sulfatase_C; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..580
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 750 AA; 82938 MW; 64041BB563CA8912 CRC64;
MGMKTVSLTW DHLITLYRPL RLEQCFAHRK RLTNTNIIII ITTFSGCFSV VIPIFQVREW
RPSEVIYPRS HCREVGEEGG IDPRWSEFQA WALASKVERR EGETCTAGAR SSPYPVPLGG
CRVFGLEHEG LASPHPLSPP PAFSCFFLLS PASLLLLLQR PEGRGRPRRS SFAIMPVICL
LLGALGLCSA ADSKPNILLI MADDLGIGDV GCYGNDTLRT PNIDRLAKEG VKLTQHLAAA
PLCTPSRAAF LTGRHAFRSG MEASNGYRVL QWNGGSGGLP INETTFAKIL QQQGYATGLI
GKWHQGVNCE SRNDSCHHPL NHGFDFFYGM PFTLINDCQI GKPPHMDAAF RAKLWFSTQV
MVLAVLTLTL SKVTGLAPVS WTVILGCGLL TLLFFLCWYS SLGFVRYWNC LLMRNYEVTQ
QPMVLEKAAP LMLKEAISFI QRNRKGPFLL FVSLLHVHIP LVTTERFRGK SKHGAYGDSV
EEMDWLIGEI LATIEEEGLT NRTLTYFTSD HGGHLEAREG VSQLGGWNGR YKGGKGMGGW
EGGIRVPGIF RWPGVLPAGG VIDEPTSLMD ILPTVASLGG GTLPRDRVID GQDLMPLLKG
AVQHSPHEFL FHYCGKHLHA VRWHQKSSGA VWKVHYVTPV FHPEGAGACY GREICPCFGA
HVTHHDLPLL FDLSGDPSEA NPLSPATEPL FGTVLERVER AVEAHRRTIT PVPQQFSLSN
IVWRPWLQPC CGTFPFCFCD TEADLSSPRP
//
