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Database: UniProt
Entry: F6UXG0_HORSE
LinkDB: F6UXG0_HORSE
Original site: F6UXG0_HORSE 
ID   F6UXG0_HORSE            Unreviewed;      4851 AA.
AC   F6UXG0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013055};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013055};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013055, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013055, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013055,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013055}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013055};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013055}.
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DR   PaxDb; F6UXG0; -.
DR   Ensembl; ENSECAT00000016179; ENSECAP00000013055; ENSECAG00000013267.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F6UXG0; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; -.
DR   ExpressionAtlas; F6UXG0; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4164   4188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4392   4412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4460   4479       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4591   4609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4652   4673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4732   4755       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      323    380       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      571    782       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      998   1194       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1240   1452       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3899   3934       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4851 AA;  550170 MW;  6403CF4556D83C0D CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHVSS GLWVTYKAQD AKTSRLGPLK
     RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ FVSSVNTLLG NNRTTAPVTL
     PIEEVLQTLQ DLIAYFQPPE EEMQHEDKQN KLRSLKNRQN LFKEEGMLAL VLNCIDRLNI
     YNSVAHFAGI AREESGMAWK EILNLLYKLL AALIRGNRNN CAQFSNNLDW LISKLDRLES
     SSGILEVLHC ILIESPEALN LIAEGHIKSI ISLLDKHGRN HKVLDVLCSL CLCNGVAVRA
     NQNLICDNLL PRRNLLLQTR LINDVTSIRP NIFLGVAEGS AQYKKWYFEL IIDQVDPFLT
     AEPTHLRVGW ASSSGYAPYP GGGEGWGGNG VGDDLYSYGF DGLHLWSGRI PRAVASINQH
     LLKSDDVVSC CLDLGVPSIS FRINGQPVQG MFENFNTDGL FFPVVSFSAG VKVRFLMGGR
     HGEFKFLPPT GYAPCYEALL PKEKMRLEPV KEYKRDAEGV RDLLGTTQFL SQASFIPCPI
     DTSQVVLPPH LEKIRDRLAE NIHELWGMNK IELGWTFGKI RDDNKRQHPC LVEFSKLPET
     EKNYNLQMST ETLKTLLALG CHIAHVNPAA EEDLKKVKLP KNYMMSNGYK PAPLDLSDVK
     LLPPQEILVD KLAENAHNVW AKDRIKQGWT YGIQQDLKNK RNPRLVPYAL LDERTKKSNR
     DSLREAVRTF VGYGYNIEPS DQELADPAVE KVSIDKIRFF RVERSYAVRS GKWYFEFEVV
     TGGDMRVGWA RPGCRPDVEL GADDQAFVFE GSRGQRWHQG SGYFGRTWQP GDVVGCMINL
     DDASMIFTLN GELLITNKGS ELAFADYEIE NGFVPICSLG LSQIGRMNLG MDASTFKFYT
     MCGLQEGFEP FAVNMNRDVA MWFSKRLPTF VNVPKDHPHI EVVRIDGTMD SPPCLKVTHK
     TFGTQNSNAN MIYCRLSMPV ECHASFSHSP CLDSDAFQKR KQMQEILSHT TTQCYYTIRI
     FAGQDPSCVW VGWVTPDYHL YSEKFDLNKN CTVTVTLGDE RGRVHESVKR SNCYMVWGGD
     IVATSQRSSR SNVDLEIGCL VDLAMGMLSF SANGRELGTC YQVEPNTKVF PAVFLQPTST
     ALFQFELGKL KNAMPLSAAI FKSEEKNPVP QCPPRLDIQT IQPVLWSRMP NSFLKVETER
     VSERHGWVVQ CLEPLQMMAL HIPEENRCVD ILELCEQEDL MLFHYHTLRL YSAVCALGNS
     RVAYALCSHV DLSQLFYAID NKYLPGLLRS GFYDLLISIH LASAKERKQM MKNEYIIPIT
     SSTGKIRLYP DESKRHGLPG VGLRTCLKPG FRFSTPCFVV TSEEHQKQSP EIPLEILKTK
     ALSMLTEAVQ CSGAHIRDPV GGSVEFQFVP VLKLIGTLLV MGVFDDDSVR QILLLIDPSV
     FGEHSGEMEE GAEKEEVTQV EEKAVEAGEK ASKEAPVKGL LQTRLPESVK LQMCELLSYL
     CDCELQHRVE AIVAFGDIYV SKLQANQKFR YNELMQALNM SAALTARKTR EFRSPPQEQI
     NMLLNFQLGE NCPCPEEIRE ELYDFHEDLL IHCGVPLEEE EEEEEDTSWT GKLRALVYKI
     KGPPKPEKEL PTEEEERCPT TLKELISQTM IRWAQEDQIQ DAELVRMMFN LLRRQYDSIG
     ELLQALRKTY TISQASVSDT INLLAALGQI RCLLSVRMGK EEELLMINGL GEIMNNKVFY
     QHPNLMRVLG MHETVMEVMV NVLGAEKSQI AFPKMVASCC RFLCYFCRIS RQNQKAMFEH
     LSYLLENSSV GLASPSMRGF TPLDVAASSV MDNNELALGL EEPDLEKVVT YLAGCGLQSC
     PMLLAKGYPD VGWNPIEGER YLSFLRFAVF VNSESVEENA SVVVKLLIRR PECFGPALRG
     EGGNGLLAAM QGAIKISENP ALDLPSQGYK REVSTEDAED DEIVHMGNAI MSFYSALIDL
     LGRCAPEMHL IQTGKGEAIR IRSILRSLVP TEDLVGIISI PLKLPSLNKD GSVSEPDMAA
     NFCPDHKAPM VLFLDRVYGI KDQTFLLHLL EVGFLPDLRA SASLDTVSLS TTEAALALNR
     YLCSAVLPLL TRCAPLFAGT EHYTSLIDST LQTIYRLSKG RSLTKAQRDT IEECLLAICN
     HLRPSMLQQL LRRLVFDVPQ LNEYCKMPLK LLTNHYEQCW KYYCLPSGWG SYGLAVEEEL
     HLTEKLFWGI FDSLSHKKYD QDLFRMALPC LSAIAGALPP DYLDTRISAT LEKQVSVDAD
     GNFDPKPINT VNFSLPEKLE YIVTKYAEHS HDKWACDKLY EKWKYGISLD ENVKTHPLIR
     PFTLTEKEKE IYRWPARESL KTMLAVGWTI ERTKEGEALV QQRENEKLRS VSQASQGNSY
     SPAPLDLSNV VLSRELQGMV EVVAENYHNI WAKKKKLELE SKGGGSHPLL VPYDTLTAKE
     KFRDREKAQD LFKFLQVNGI VVSRGMKDME LDASSMEKRF AYKFLKKILK YVDSAQEFIA
     HLEAIVSSGK TEKSPHDQEI KFFAKVLLPL VDQYFTNHRL YFLSSPLKPL SSSGYASHKE
     KEMVASLFCK LAALVRHRIS LFGNDSTTMV SCLHILAQTL DTRTVMKSGS ELVKAGLRAF
     FENAAEDLEK TSENLKLGKF THSRTQIKGV SQNINYTTVA LLPILTSIFE HVAQHQFGVD
     LLLGDVQISC YHILCSLYSL GTGKNIYVER QRPALGECLA SLAAAIPVAF LEPTLNRYNP
     LSVFNTKTPR ERSILGMPDT VEEMCPDVPQ LEGLMKEIND LAESGARYTE MPHVIEVILP
     MLCNYLSYWW ERGPEHLPPS TGPWCTKVTS EHLSVTLGNI LKIINNNLGI DEASWMKRIA
     VYAQPIISKA RPGLLRSHFL PTLEKLKKKA VKTVQEEEQL KADSKGDTQE AELLILDEFA
     VLCRDLYAFY PMLIRYVDNN RSNWLKSPDA YSDQLFRMVA EIFILWCKSH NFKREEQNFV
     IQNEINNLAF LTGDSKSKMS KAMQVKSGGQ DQERKKTKRR GDLYSIQTSL IVAALKKMLP
     IGLNMCTPGD QELISLAKSR YSYKDTDEEV KEHLRNNLHL QEKSDDPAVK WQLNLYKDVL
     KSEEPSNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA VVACFRMAPL
     YNLPHRSINL FLHGYQRFWI ETEEYSFEEK LVQDLAKSPK VEEEEEEETE KQPDPLHQII
     LHFSRNALTE RSKLEDDPLY TSYSSMMAKS GEEEEEEEDK EKTFEEKEME KQKTLYQQAR
     LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN AGVQQKMLDY LKEKKDAGFF
     QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE RGEKILQNDE FTRDLFRFLQ
     LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH
     NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ
     IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV ESSTNVEMIL KFFDMFLKLK
     DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG QKQYIQSEID FLLSCAEADE NDMFNYIDFV
     DRFHEPAKDI GFNVAVLLTN LSEHMPNDSR LKSLLDPAES VLNYFEPYLG RIEIMGGAKK
     IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS
     QISESDSADR PEEEEQAEED SSYMLEIEGE EEDDRSFESV SAFAMACASV RRNVANFLKR
     ATLKNLRKQY RKVKKMTVKE LVKVFFSFFW TLFVGLFQLF FTILGGIFQI LWNTVFGGGL
     VEGAKNIRVT KILGDMPDPT QFGIHDDALE AERAEVTEPG IATELVYFVK GEKGDADIMS
     DLFGYHSKKE SGLKHGPEVG LGDLSEIIGK DEPPTLESAV QKKRKAQAAE MKAAHEAEGK
     VESEKADMED GEKEDTAKEE VQAEALWAEA TKKKKRRCGQ KVEKPEAFMA NFFKGLEIYQ
     TKLLHYLARN FYNLRFLALF VAFAINFILL FYKVTEEPLE EETEDVANLW NSFNDEEEEE
     AMVFFVLQES TGYMAPTLRA LAIIHTIISL VCVVGYYCLK VPLVVFKREK EIARKLEFDG
     LYITEQPSED DIKGQWDRLV INTPSFPNNY WDKFVKRKVI NKYGDLYGAE RIAELLGLDK
     SALDFSPVEE TKAEAASLVS WLSSIDMKYH IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN
     FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS
     EDDDEPDMKC DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DPYEMYRIVF DITFFFFVIV
     ILLAIIQGLI IDAFGELRDQ QEQVREDMET KCFICGIGND YFDTTPHGFE THTLQEHNLA
     NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE RCWDFFPAGD CFRKQYEDQL G
//
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