ID F6UYF5_HORSE Unreviewed; 1196 AA.
AC F6UYF5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
GN Name=CGN {ECO:0000313|Ensembl:ENSECAP00000013039.2,
GN ECO:0000313|VGNC:VGNC:16470};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013039.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000013039.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013039.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000013039.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013039.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC tight junction (TJ) paracellular permeability barrier.
CC {ECO:0000256|ARBA:ARBA00043864}.
CC -!- SIMILARITY: Belongs to the cingulin family.
CC {ECO:0000256|ARBA:ARBA00038467}.
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DR RefSeq; XP_001492565.1; XM_001492515.3.
DR RefSeq; XP_014595420.1; XM_014739934.1.
DR AlphaFoldDB; F6UYF5; -.
DR SMR; F6UYF5; -.
DR STRING; 9796.ENSECAP00000013039; -.
DR PaxDb; 9796-ENSECAP00000013039; -.
DR Ensembl; ENSECAT00000016160.3; ENSECAP00000013039.2; ENSECAG00000015048.3.
DR GeneID; 100059886; -.
DR KEGG; ecb:100059886; -.
DR CTD; 57530; -.
DR VGNC; VGNC:16470; CGN.
DR GeneTree; ENSGT00940000162698; -.
DR HOGENOM; CLU_002036_0_0_1; -.
DR InParanoid; F6UYF5; -.
DR OMA; HWREMFQ; -.
DR OrthoDB; 4226071at2759; -.
DR TreeFam; TF332247; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000015048; Expressed in trophoblast and 16 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR InterPro; IPR002928; Myosin_tail.
DR PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 756..1145
FT /note="Myosin tail"
FT /evidence="ECO:0000259|Pfam:PF01576"
FT REGION 79..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 135789 MW; 446BD7CB15039A35 CRC64;
MEQASTMAEP RGPVDHGVQI RFITEPVDDA EMGTLRRGGR RPAKDARAST YGVAVRVQGI
AGQPFVVLNS GEKGGDSFGV QIKGANNRGA PGALSSNSEL PKNPYSRAKE FPAPSQGSLS
DEEPGAPWNG RLLRSQSHAS LTGPAPLGPS NRSTSLLELA PQGASPGSTI DTAPLSSVDS
LISKFDRQHG SQARGRTGRR MRTLPPEQRK RSQSLDNRIP RDTLEEGEHR SPNHLTPSAK
HDDHMGSSKQ LAQSQSSGFS RTRQTRDWVL QSFEEPRGRA QDSAMLQLKS TPDLLRDQQE
ATPAGSVDHV KATIYGILRE GSSESETAVR RKVSLVLEQM QPLVMASPGS AKALGGHGEL
TQKVEELQQK LDEEVKKRQK LEPSRLGLER QLEEKAEECS RLQELLERRK GEAQQSTKEL
QNMKLLLDQG ERVRHGLETQ VMELQDKLKQ AQGPEPAKQV LMKDLLETRE LLQEVLEGKQ
QIEEQLRLRE RELTALKGAL KEEVASRDQE VEQVRQQYQR DTEQLRRSMQ DATQDHATLE
AERQKMSALV RELQRELEET SEETGHWQSM FQKNKEELRA TKQELLQLRM EKEEMEEELG
EKMEALQREL GQARASAGDV RQVEELKKEL CRTQEELKEL QAEGQSQQVA GRHREQELEK
QLKVEADRGQ ELEQQNLQLQ KTLQQLRQDC EEASKAQMAA EAEAAVLGQR RSAVETTLRE
TQEENDEFRR RILGLEQQLK EARGLAEGGE VVEARLRDKV QRLEAEKQRL EEALNAAQEE
EGSLAAAKRA LEARLEEAQR GLARLGQEQQ ALNRALEEEG KQREVLRRGK AELEEQKRLL
DRTVDRLNKE LEQIGDDSKQ ALQQLQAQLE DYKEKARREV ADAQRQAKEW ASEAEKTSGG
LSRLQDETQR LRQALQASQA DRDTARLDKE LLAQRLQGLE QEAETKKRSQ DDRTRQLKGL
EEKVSRLEAE LDEERSTVEL LTDRVNRGRE QVDQLRTELM QERSARQDLE CDKISLERQN
KDLKSRLASS EGFQKPSASL SQLESLNREL QERLQAEERE KTVLQSTNRK LERRVKELSI
QIDDERQHVN DQKDQLSLRV KALKRQVDEA EEEIERLDGL RKKAQRELEE QHEVNEQLQA
RIKALEKDSW RKTSRSAAES ALQHEGLSSD EEFDGVYDPS SIASLLTESN LQTSSC
//
