ID F6V181_ORNAN Unreviewed; 1401 AA.
AC F6V181;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G3 {ECO:0000313|Ensembl:ENSOANP00000009975.3};
GN Name=PLEKHG3 {ECO:0000313|Ensembl:ENSOANP00000009975.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000009975.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000009975.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009975.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000009975.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000009975.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9258.ENSOANP00000009975; -.
DR Ensembl; ENSOANT00000009977.4; ENSOANP00000009975.3; ENSOANG00000006235.5.
DR eggNOG; KOG3518; Eukaryota.
DR GeneTree; ENSGT00940000156521; -.
DR HOGENOM; CLU_007600_0_0_1; -.
DR InParanoid; F6V181; -.
DR OMA; PCVEDLM; -.
DR TreeFam; TF328565; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000006235; Expressed in adult mammalian kidney and 8 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IBA:GO_Central.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 146..324
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 348..446
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 46..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1194..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..618
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1401 AA; 155662 MW; 9F5BADB38E3C12EF CRC64;
MSLRWLHFEE VAFITEAITL IPLGVLKRNV TGALLISEES LPATLPAGRD ERMPVSASLH
PDSTQERPAS LTSTASSSGS SRDSRAMEEP GVGEPGPEGG EGAPQGLPHF NSNNSASSWL
NGQGGPSFSA FASRAPAGDN HLQHSYLGRV VREIVETERM YVQDLRSIVE DYLLKIIDTP
DLLEPEQVSA LFGNIEDIYE LNSQLLKDLD GCNGDPVAVA YCFVDRREEF DIYTQYCTNY
PNSVAALTEC MREKHQAKFF RDRQELLQHS LPLGSYLLKP VQRILKYHLL LQEIAKHFDR
EEGLEVVELA IYTMTCVAWY INDMKRKHEQ AVRLQEIQSL LINWKGPDLT TYGELVLEGT
FRVHRVRNER TFFLFDKALL ITKKRGDHFV YKTHIPCSSL MLIESTRESL CFTVSHYKHN
KQQYSIQAKS ADEKRGWTHH IKRLILENHH TTIPQKVKEA ILEMDSYYPT RYRYSPDRLK
KAMDEAPLQR CQGRRRSEPT KQLLKQLNQK ARPAGLKHSD SAEALLDSGE FRQPLFPWGP
QSDFERADQE QDEKEEEEEQ AFQHQTSLED LPLSNGSEKR AGAEPQGSEE EEEEEKEEEE
EKEEEEEEEE EEESLEVAEQ VADFASSLLA ALHCWHYRAN ALLFSRGATD SGPSEHEVAK
GCKRPSGQSS SSPQKCVNLA PDSSGSETWL DGDPEVVPGP APPPLDHSPE RPSDLESSPR
TPERLLSLPE EVLATDLPAP EVEHVLPESQ EDLKTLSSEE EEEEEGAAQE SGSILPPSVL
DQASVIAEKF ISSFSRRSSL ALEDGRSGGF GQVHLTGQSG SLLSLEGGEK GLYPSSPSDS
TDCFLAPEVA SGARAAREPR SPLDRPVPPS PGGPGEAERS PFKKKESLLS TQDRLLLDRI
KNYYDHAEHH DASFSIRRRE SFSYIPKGLV RNSVTKFNSF PRPEPRAPAE RKRLAGLWPT
SGTRSDLPTP GQGDPGDPAP VRDSEFRPSS ELVKIWDGMD RSSGARRGLV GKGRREPGSG
QENGFDLHEP LFILEEHELG AIAEELPGAS SHSPQTHPAQ LARELKELVK ELGSGEPELP
TTLHPRIVQF SHMMDADLGE RVTNKVYQLA RQYSLRIKRH KPVGPNRSKG EPDGGSPGPK
LPLVLEEVSR PAASRGKKPA LSLPRSERLV VEGDSWPRHS SFARSQTLPC CSFGPSSSGR
WDPSSLGDQR PPAHGTLSPT DGETFHWPDV RQLCSRYACG AGAPQARLGP RRGPPVSRSR
SVPNGMMEPA QSGHVNRCLS LEAPRGQEDE ALFVAADVIL DDNRRVIVLE KGPLPEPHNM
AEEGERDSYG QCRSPTSREK ISQMAVVEHR KAYQESEEPR GRKEGPAPDS LLPNPRVMAG
SGQQGLVRTL RAKFQTLNSN G
//
