ID F6V5B8_HORSE Unreviewed; 593 AA.
AC F6V5B8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Calpain 5 {ECO:0000313|Ensembl:ENSECAP00000013272.3};
GN Name=CAPN5 {ECO:0000313|Ensembl:ENSECAP00000013272.3,
GN ECO:0000313|VGNC:VGNC:16041};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013272.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000013272.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013272.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000013272.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013272.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR AlphaFoldDB; F6V5B8; -.
DR Ensembl; ENSECAT00000016431.3; ENSECAP00000013272.3; ENSECAG00000015125.4.
DR VGNC; VGNC:16041; CAPN5.
DR GeneTree; ENSGT00940000156536; -.
DR TreeFam; TF314748; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000015125; Expressed in bone marrow and 22 other cell types or tissues.
DR ExpressionAtlas; F6V5B8; baseline.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04046; C2_Calpain; 1.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033884; C2_Calpain.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF402; CALPAIN-5; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 55..299
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 455..570
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 208
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 240
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 593 AA; 67719 MW; 1826E507876C5EEB CRC64;
MFSGVKPYEN QNYSALKRAC LRRKVLFEDP NFPATDDSLY YQGAPGPAVR WKRPKVIPDW
KEQEWDPKKP DAYAGIFHFH FWRFGEWVDV VIDDRLPTVN NQLIYCHSSS RNEFWCALVE
KAYAKLAGCY QALDGGNTAD ALVDFTGGVS EPIDLTEGGF AHDEAKRNEL FERVLKVHSR
GGLISASIKA VTAEDMEARL ACGLVKGHAY AITDVRKVRL GHGLLTLFKS EKLDMIRLRN
PWGEREWNGP WSDTSEEWQQ VSKSEREKMG MTVQDDGEFW MTFKDLCQYF TDIIKCRLIN
TSYLSIHKTW EEARLHGAWT HHEDPHQNRS GGCINHKDTF FQNPQYIFDV KKPEDEVLIC
IQQRPKQSTR RGGKGENLAI GFDIYQVEEN RQYRMHSLQH RAASSIYINS RSVFLRTEQP
EGRYVIIPTT FEPGHTGEFL LRIFTDVPSS CRELRLDEPP RSCWSSLCGY PQQVTQVHVL
AAAGLKESPS EPNSYVIIKC EGDKVRSAVQ KGTSKPEYNV KGIFYRKKPG QSITIQIWNH
RVLKDEFLGQ VCLKADPDDL QALHTLRLQD RNNGQSSDLP GTIAALVASQ PLG
//
