ID F6V606_MONDO Unreviewed; 2513 AA.
AC F6V606;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Polycystic kidney disease and receptor for egg jelly-related protein-like {ECO:0000313|Ensembl:ENSMODP00000033121.2};
GN Name=LOC100028573 {ECO:0000313|Ensembl:ENSMODP00000033121.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000033121.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000033121.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000033121.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007502676.1; XM_007502614.2.
DR STRING; 13616.ENSMODP00000033121; -.
DR Ensembl; ENSMODT00000034699.2; ENSMODP00000033121.2; ENSMODG00000024114.2.
DR GeneID; 100028573; -.
DR KEGG; mdo:100028573; -.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000162080; -.
DR HOGENOM; CLU_001765_0_0_1; -.
DR InParanoid; F6V606; -.
DR OMA; KNHMWFS; -.
DR OrthoDB; 52189at2759; -.
DR TreeFam; TF316484; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000024114; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2513
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023863596"
FT TRANSMEM 1412..1432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1830..1858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1870..1892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1967..1991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2225..2248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2260..2280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2300..2323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2343..2366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2406..2432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 455..1144
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1457..1574
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 54..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..79
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1777..1795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2513 AA; 284487 MW; 9B1ADC0E3387FFA9 CRC64;
MLRGGALLCF LLLLPPRLLP LHRSSPSIAP VASAPARRAS RQSLQRRLQV LLLPSRGSHR
GPDFPPNPRP GPNLGFPLGQ DPEPDPVAAS DCGSKWDLAL GSKPAPGPGC QGALCPPLPP
QFKPRSGPSS VPGRPAEAAL LHILSASSLP LSQRSSGALH LSWGLQPSGS KLTFRLYQPQ
GQDHHQVWKV TCNPYLGAGG GLFCSPGPSP DLGAPKWTLA HLLLPGRGWA WGSRQVIGPA
LEGDLHLVNS TLGIRARGST LSLNLRQAQT GSHGHGIYYS RAAPGHGRAW QAQTHLLFYQ
QQGLSWLFAL DRWDRLSVHL SLSPKGVAFF GCRPPRDLEV HFFSSSPLKA NGLFYLLWFI
PLQHPLLRPQ WTFHLQLPGT SLGLNRTYTY QDRIPRASRF IQRSVLPFRP DGYAGFVEKA
NCATSSLEPV ILEASLDKYG SKVLRTPVAC VQNPCYIKRM KILLNAPIER GLIAPHYDNS
VLVEVICSVP YNSSHHWSVF KLPSDTDPKP SKENIVTGQK STFSVPSTIL KPGTYRLNYT
LTITTSEQVA TSSTFRDFTV SPPILYAYIE GGPARSVPFN KRWTLDGSRS RNVWYYTDPK
IMKYRWYCTT NYTYFIIGNL PASSRDSCLP KLPDVRWFKA TSPVVTVSPG TLRGNRTYYF
ILVVSLFSNR AYAYQNVTVE PGPPPKMKFS CIENCGKLLV VPDRLSLSSK CLDCGARPMK
YLWSLMDSTK TEIPFNWTHW STTGRTSTYL TIKAFAFKDF QDKMCSAILH ASGWGGNFLV
ANHSFYVNSP PRNGYCDIHP NKGVALFTKF VVRCSGFIDE NLPLHFKVIA SNFWGVDNSS
TVADNTLGTV MYFGLESVTP PSFLPIGMPV NHYMVRVYAQ VYDFLGAFSQ VTLHATVTSP
QDRASPNTVL NYLLSLTQNT TGTMMTTLFQ KGDFVQAGYL AYLAVSLLND VTPPPNLQAQ
YSEIQHHLLN VCRHLPTTTL EEINQVTVMI MGLTKKGSGL TAEGQKAATS RLIEINLALQ
RLKEKEKEFL SEQIQIVSTS ILSCLSNILK SEINEDMINE TLHVIELLAS TVLAVKSPGE
METVVTSPHL RISVWKDEKR NVNDAFLAQK DCQNCFYPTL RKNDSEYLAR GGPISTAFYE
FKQELSTSED TGLSTDVVGF QMSEIKENGN IQEVIPDLVE VFLLRKNLSG AAFNITMGPD
KDLPETTSGV FTFLVFGTDE EVLIQIITEV KVMFKAFIYE GSNVTHSLPI ASFLVPPDMP
TVANESKLFD PTCKVKFKVP RLICLSQSLL EATVQDYFAS NWSISVVLQT PPIVMVPSDQ
LVNISIFLAE CLKMEGNEKE WDKEDCKVGD KSSWWRIHCI CEIKSKPMNE SKPGESWKRL
SRIKYLSARM IVIPNSIDLR MEILKTIPQN PVAVFTVVLI IFTYLVLAFW AMHKDETDRI
RREHVILLPD NDPYDHICYL VTFYTGSRLG AGTKADVFVQ LLGTDASSDV HCLSHPNFTT
FYRGSTDSFL LTTRSDLGNL RAIRVWHNNE GSDPSWYLSR VKIENIFNRN IWLFLCRSWL
SINKSLEQTF PVADKGQPMN KKDYFQIFAS DNLGTRHLWL SVFSSVVTGP FNRLQRLSCC
LTLLMNTLLC NIMFFNVEKE VEVSPMELKF LRTIMRGIES ALICEPMQIL LVSLFTYSHR
KVKPVAITQV APHVHPFMKS PFQNWKERLE MWYSLETAHK QAPGRSFLRK MQAQGSNVTI
PEAVANAITE TEEKPPNSEA FLEKNMTNTK PVDVAISREE QTSEESLSSS ASLVRRSDAA
KEDQGAEPAS EESPQKSPKK VLLFEAKPRF FFHWWCIYVA WLLVIGSSGV SSFFIIMYGL
TYGYEKSMDW LISSMTSLTE SIFIIQVAKI LLVSGIRSGR ATYCKNIPWA SRYNYLEIRL
QELELNADDS RELHYEIIRI RGTRMYQPLV QDEIRIFRRR KKIRDRALIF LKNIISHLIF
LTLLFCIISL ARPSHSFHHN QAMQNQFSLK LTTITKLDDI YRWLTGVWLP LIHNDENPTF
ISNSWSKILG SPKMRQVRAK SIKRECFLSG TMVDKLMKKG IHCHSQYSQV MEDQKNYGRL
WSTRSKFSVD PRPVSFTYEP NLRKWSYYSY GLSHAYGSGG YPFYFFPTQK QYNSTVRLQE
LQESRWLDEK TWAVILELTT FNSDTSLFCT ISIVFEASPF GVINPSLAIH SFSLPLIYRE
SYFELYLYGG ALMFIVLLLI DEATIIYWEK ENYVKNVFNF LSLGLKLMFL MLILLFFVKF
RLTKDILGFY LQNPDGFTPF HVISLVDQGL GIILGFLGFL TILKTLTYSR FFYDIRLAQT
TILAALPGIF HMALLVGVYI FMYVTFGRLV FGQHEWHYSN LIHSTQTIFS YCVSAFRDTA
FLNKEVLGGL FLASFMLVMI CILINLFQAV FLSTYEEMKQ LVYEEPAAEG EAITFLFHKV
RNLWRTLTCR KPFREQPTYF SDILYGHPGN QSHQRLGLKS RNINGKRVTY VAV
//
