ID F6V6M0_CIOIN Unreviewed; 701 AA.
AC F6V6M0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
DE AltName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000024039.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000024039.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; EAAA01002955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6V6M0; -.
DR STRING; 7719.ENSCINP00000024039; -.
DR Ensembl; ENSCINT00000024285.2; ENSCINP00000024039.2; ENSCING00000013004.2.
DR GeneTree; ENSGT00940000156374; -.
DR HOGENOM; CLU_003901_0_3_1; -.
DR InParanoid; F6V6M0; -.
DR OMA; CTVSIGC; -.
DR TreeFam; TF314488; -.
DR Proteomes; UP000008144; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0017125; F:deoxycytidyl transferase activity; IBA:GO_Central.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR GO; GO:0070987; P:error-free translesion synthesis; IBA:GO_Central.
DR GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR HAMAP; MF_01113; DNApol_IV; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR PIRSF; PIRSF036573; REV1; 2.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 33..123
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 255..436
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 701 AA; 77997 MW; BA7AC73BBABFCF28 CRC64;
MSDDGWSSMG GYMEAKIQKL EKQFQEKSSR NEQLSSIFNK VAIHVNGYTN PTADELKTLM
AKHGGKYHAY YNRKINYTTH VIASNLPRAK AKDLKPNQKI VRPEWIVESI TAGTLLPIQP
YLLVANSSVS RQKILTSKKE GELLDAFFSS NPSTSKCIED TTPQVKPEAG ENTPQCSTVV
ANHVNQQANS RTSKIAATTD SGFLDEFYAN SRLHFISTWK NDLADFFKVT VTKQSTSYWK
RRIIEIDERA KSKVIMHIDM DCFFVSVGLL SRPHLKGRPV AVTHHSSYSE IASCSYEARA
AGLRNGMFYG RAKELCPDLI AIPYDFEAYK DISQKLYTVL ASYTQSLEAV SCDEALLDVT
QLVEDTSLTP QVIAQNIRGK ILDATGCNAS AGIGPNIALA RMATRLGKPN GQHEVTLQQA
EEFIRDLPVK DLPGVGRATA SRLRELGAST CGELQKIHPD LLKKEFGNKT GQKLHELSKG
IDEREVCQSK ERKSVSADVN YGIRLKTEDE MKTFLNNLSN EVSSRLKKTG LSGKKITLKV
MVRHSDAPVE TAKFKGHGVC NSISRSKNLN EYTDDCDIIG REGITLMKSL QLNVTDLRGI
GIQLSTLTST SSLSKSRLSI QQFIKKGKSC RKSSDMQIIT PEKKIDSEKK NVRLMILPSS
VLLIPSHSND SINTSFLDAL PEELRKEIEK DYKAQKNALQ Q
//
