ID F6V7B1_HORSE Unreviewed; 240 AA.
AC F6V7B1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Tissue factor pathway inhibitor {ECO:0000256|PIRNR:PIRNR001620};
GN Name=TFPI2 {ECO:0000313|VGNC:VGNC:24046};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016920.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016920.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016920.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016920.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016920.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001620}.
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DR AlphaFoldDB; F6V7B1; -.
DR STRING; 9796.ENSECAP00000016920; -.
DR MEROPS; I02.013; -.
DR PaxDb; 9796-ENSECAP00000016920; -.
DR Ensembl; ENSECAT00000020601.3; ENSECAP00000016920.3; ENSECAG00000019398.3.
DR CTD; 7980; -.
DR VGNC; VGNC:24046; TFPI2.
DR GeneTree; ENSGT00940000159917; -.
DR HOGENOM; CLU_058441_1_0_1; -.
DR InParanoid; F6V7B1; -.
DR OMA; QFMYGGC; -.
DR OrthoDB; 3558236at2759; -.
DR TreeFam; TF315349; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000019398; Expressed in endometrium and 19 other cell types or tissues.
DR ExpressionAtlas; F6V7B1; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-UniRule.
DR CDD; cd22615; Kunitz_TFPI1_TFPI2_3-like; 1.
DR CDD; cd22616; Kunitz_TFPI2_1-like; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 3.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008296; TFPI-like.
DR PANTHER; PTHR10083; KUNITZ-TYPE PROTEASE INHIBITOR-RELATED; 1.
DR Pfam; PF00014; Kunitz_BPTI; 3.
DR PIRSF; PIRSF001620; TFPI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 3.
DR SUPFAM; SSF57362; BPTI-like; 3.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084,
KW ECO:0000256|PIRNR:PIRNR001620};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696, ECO:0000256|PIRNR:PIRNR001620};
KW Protease inhibitor {ECO:0000256|PIRNR:PIRNR001620};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Serine protease inhibitor {ECO:0000256|PIRNR:PIRNR001620};
KW Signal {ECO:0000256|PIRNR:PIRNR001620}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|PIRNR:PIRNR001620"
FT CHAIN 26..240
FT /note="Tissue factor pathway inhibitor"
FT /evidence="ECO:0000256|PIRNR:PIRNR001620"
FT /id="PRO_5040556999"
FT DOMAIN 36..86
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 96..146
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 161..211
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 240 AA; 27029 MW; 44D85D70518C779B CRC64;
MDAAHPLGLL LLPLLLMGTV LGAAAQVPSG NNAEICLLPP DEGPCRARIP SYYYDRYTQS
CRQFIYGGCE GNANNFETWA ACDEACWRIE KVPKICRLEV SEGQCGEPRK QYFFNLSSMT
CEKFISGGCH SNENQFPDEA TCMGFCAPKK SKYYFYGPSF CYSPKDEGLC SANVTRYYFN
PRHKACEAFT YTGCGGNDNN FVNRKDCKQV CAKGLKKKKN KKMKTLFLAN RSLKLQKKQF
//
