ID F6V7L7_MACMU Unreviewed; 1762 AA.
AC F6V7L7; A0A1D5QZD8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Laminin subunit beta 4 {ECO:0000313|Ensembl:ENSMMUP00000028035.4};
GN Name=LAMB4 {ECO:0000313|Ensembl:ENSMMUP00000028035.4,
GN ECO:0000313|VGNC:VGNC:74231};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000028035.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000028035.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000028035.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 9544.ENSMMUP00000053420; -.
DR PaxDb; 9544-ENSMMUP00000028035; -.
DR Ensembl; ENSMMUT00000029956.4; ENSMMUP00000028035.4; ENSMMUG00000021289.4.
DR Ensembl; ENSMMUT00000053728.2; ENSMMUP00000053420.2; ENSMMUG00000021289.4.
DR VEuPathDB; HostDB:ENSMMUG00000021289; -.
DR VGNC; VGNC:74231; LAMB4.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000162514; -.
DR HOGENOM; CLU_001560_1_0_1; -.
DR OMA; RRCSCHP; -.
DR OrthoDB; 90222at2759; -.
DR TreeFam; TF312903; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000021289; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd22301; cc_LAMB4_C; 1.
DR CDD; cd00055; EGF_Lam; 12.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1762
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197264"
FT DOMAIN 24..264
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 265..331
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 332..394
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 395..454
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 455..505
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 545..763
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 769..816
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 817..862
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 863..910
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 970..1021
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1022..1079
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1080..1127
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1128..1174
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1268..1295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1423..1450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1526..1625
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1653..1680
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1715..1756
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 477..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 489..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 769..781
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 771..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 790..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 817..829
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 819..836
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 838..847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 882..891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 894..908
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 994..1003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1052..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1080..1092
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1082..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1101..1110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1128..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1130..1147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1149..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1762 AA; 193659 MW; 8B39A7AC82DFADF3 CRC64;
MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLTASSTCG LSRAQKYCIL
SYLEGEQKCF ICDSRFPYDP YTQPNSHTIE NVIVSFEPDR EKKWWQSENG LDHVSIRLDL
EALFRFSHLI LTFKTFRPAA MLVERSTDYG HTWKVFKYFA KDCATSFPNI TSGQAQGVGD
IVCDSKYSDI EPSTGGEVVL KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDTL
LGRRQNDSLD KYYYALYEMV VRGSCFCNGH ASECRPMQKV RGDVFSPPGM VHGQCVCQHN
TDGPNCERCK DFFQDAPWRP AAELQDNACR SCSCNSHSSR CHFDMTMYLA SGGLSGGVCE
DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD GTISGGICVS HSDPALGSVA
GQCLCKENVE GAKCDQCKPN HYGLSATDPL GCQPCDCNPL GSLPLLTCDV DTGQCLCLSY
VTGAHCEECT VGYWGLGNHL HGCSPCDCDI GGAYSNMCSP KNGQCECRPH VTGRSCSEPA
PGYFFAPLNF YLYEAEEAMP LQGLAPLGSE TFGQSPAVHI VLGEPVPGNP VTWTGPGFAR
VLPGAGLRFA VNNIPFPVDF TIAIRYETQS AADWTVQIMV NPTRGSEHCV PKTSQSKPQS
FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLERESYT HSHILVDSLG LIPQINSLEN
FCSKQDLDEY QLHNCVEIAS AMGPQVLPGA CERLIISMSA KLHDGAVACK CHPQGSVGSS
CSRLGGQCQC KSLVVGRCCD RCSPGSYGLG HHGCHPCHCH PQGSKDTVCD LVTGQCPCHG
EVSGRRCDRC LAGYFGFPSC RSCPCNGFAE LCDPETGSCF NCGGFTTGRN CERCIDGYYG
NPSSGQPCRP CLCPDDPSSN QYFAHSCYQN LWSSDVICNC LQGYTGTQCG ECSTGFYGNP
RISGAPCQPC PCNNNIDVTD PESCSRVTGE CLRCLHNTQG ANCQLCKPGH YGSALNQTCR
RCSCHASGVS PVECPPGGGA CLCDPVTGAC PCLPNVTGLA CDRCADGYWN LVPGRGCQSC
DCDPRTSQSS HCDQLTGQCP CKLGYGGKRC SECQENYYGD PPGRCIPCDC NRAGTQKPIC
DPDTGMCRCR EGVSGQRCDR CARGHSQEFP TCLQCHLCFD QWDHTISSLS KAVQGLMRLA
ANMEDKRETL PVCKADFKGL RENMSEIERI LKHPVFPSGK FLKVKDYHDS VRKQIMQLNE
QLKAVYEFQD LKHTIERAKN EADLLLEDLQ KEIDLQFSVL NASIVDSSEN IKKYYHISSS
AEKKINETSS TINTSANTRN DFLTILNTLT SKGNLSLEKL KQIKIPDIQI LNEKVCGDPG
NVPCVVPLPC GGAVCMGQEG HRKCGGAGCH GSLTLSTNAL QKAQEAKSVI RNLDKQVRGL
KNQIKNISKL AEVSKNNALQ LRGKLGNTRN QSDSEEEKLN LFIKKVKNFL LEENVPPEDI
EKVANGVLDI HLPIPSQNLM DEVNKIQKLM QLCEDYRSDE NRLSEEEDGA QKLLVKAKAA
EKAANVLLNL DKTLNQLQQA QITHGRANST ITQLTANITK IKKNVLQAEN QTREMKNELE
SAKQRSGLED GLALLQTKLQ RHEDHAVNVK VQAESAQHQA GSLEKEFVEL KKQYAVLQHK
TSTTGLTKET LGKVKQLKDA AEKLAGDTED KIRRITDLER KIQDLNLSRQ AKADQLRILE
DQVVAIKNEI VEQEKKYATC YS
//
