ID F6V7W7_CIOIN Unreviewed; 969 AA.
AC F6V7W7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000024019.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000024019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR EMBL; EAAA01002959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6V7W7; -.
DR STRING; 7719.ENSCINP00000024019; -.
DR Ensembl; ENSCINT00000024265.2; ENSCINP00000024019.2; ENSCING00000008460.3.
DR GeneTree; ENSGT00940000163886; -.
DR HOGENOM; CLU_308576_0_0_1; -.
DR InParanoid; F6V7W7; -.
DR OMA; IEDIHSY; -.
DR TreeFam; TF315996; -.
DR Proteomes; UP000008144; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR CDD; cd01213; PTB_tensin; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR PANTHER; PTHR45734; TENSIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 684..794
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 20..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 969 AA; 104767 MW; C13BEB2C92125C20 CRC64;
MREDAMDSFA VLEAVLAEME ALTPSPNTNR SPPSHGSSLN SDASSGLGAS PTQPVKQDVW
VKRFDFNDDV YLMNASPPSP PRPVTQKSKK SKRKTTPAIE EIGKSASVRN PTVKRKNSFR
RHTVSLHSNY VRYDDPADQL TVFRKQQVAD FYSTQLCVTN FPPNSSKRPS SAFSPYQGRQ
FFKIPEENEN ETSEYFSSDD SKDTFNEPTN DDVFSQDQNM PQPSYPPRTS HTRPPQQQMV
GRSLSSASSS GSTSAHKKSL EERLSPQLFL AMSVNPGGRP IEDIHSYKED LEPDSPKEER
SPHPATPAFP ITPKTPYTNL TSPIAHVPIG ITKTPLSELG LKPKPLELDD SKNIPGTHTP
AGVHLSSAPK QHQVTSASIN GTTQGIMTQS QVTSPQQSVH MNKTTNRSVI VENSRIRLDE
QTRPTNHQPT LESRDPSTQQ YIHGSFTPPL SQTTSYTATD RRPNGWQQNH SPHANSASPV
ATKDMRSPWV FNGDTSPIAS SPAGKSPVIS SIASSATPPH GNGSGEVSPA GTRSLNGSND
SLLSGGSASG HHPHLAYQKD RYSHNIPKDS SRHSASSIRS TSTGGSGYLG GASQTSPHSA
GSPVSGSGQY PFTHINKRES QLSAYDRHGG HHLISSDEGG LSSPASGRTS ASSVSDIEKL
AHEVSQANIA GTPPKFIKDT TAYWYKPEIN RDQAHAMLRT RPPGSFVVRA SRCYPGAFGL
ALKVHQVPAA VLATAKPGTD MNNELVRHFL IEPSTRGVKL KGCPNEPVFG SLSALIYQHS
ITPLALPCKL VIPTSNQDVP PAGSSRDSTE IQNSAVELLK QGAACNVLYL GSEDTESLTG
PEAIERAMRE CMQNVGQAIK TSVVHFKVSP QGITLTDNAR KIFFRRHYPT ATVTYCGLDP
SAREPHNRRW DASKDRGPPN ARVFGFVAKK PGSSVENVCH LFAELDLDQP APAIVNFVSK
VLIGAAGSN
//