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Database: UniProt
Entry: F6V7W7_CIOIN
LinkDB: F6V7W7_CIOIN
Original site: F6V7W7_CIOIN 
ID   F6V7W7_CIOIN            Unreviewed;       969 AA.
AC   F6V7W7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000024019.2, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA   Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA   Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA   Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA   Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA   Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA   Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA   Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA   Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA   Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA   Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA   Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA   Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000024019.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|ARBA:ARBA00004246}.
CC   -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC       {ECO:0000256|ARBA:ARBA00007881}.
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DR   EMBL; EAAA01002959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6V7W7; -.
DR   STRING; 7719.ENSCINP00000024019; -.
DR   Ensembl; ENSCINT00000024265.2; ENSCINP00000024019.2; ENSCING00000008460.3.
DR   GeneTree; ENSGT00940000163886; -.
DR   HOGENOM; CLU_308576_0_0_1; -.
DR   InParanoid; F6V7W7; -.
DR   OMA; IEDIHSY; -.
DR   TreeFam; TF315996; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   CDD; cd01213; PTB_tensin; 1.
DR   CDD; cd09927; SH2_Tensin_like; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035012; Tensin-like_SH2.
DR   InterPro; IPR033929; Tensin_PTB.
DR   PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR   PANTHER; PTHR45734; TENSIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          684..794
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          20..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..568
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   969 AA;  104767 MW;  C13BEB2C92125C20 CRC64;
     MREDAMDSFA VLEAVLAEME ALTPSPNTNR SPPSHGSSLN SDASSGLGAS PTQPVKQDVW
     VKRFDFNDDV YLMNASPPSP PRPVTQKSKK SKRKTTPAIE EIGKSASVRN PTVKRKNSFR
     RHTVSLHSNY VRYDDPADQL TVFRKQQVAD FYSTQLCVTN FPPNSSKRPS SAFSPYQGRQ
     FFKIPEENEN ETSEYFSSDD SKDTFNEPTN DDVFSQDQNM PQPSYPPRTS HTRPPQQQMV
     GRSLSSASSS GSTSAHKKSL EERLSPQLFL AMSVNPGGRP IEDIHSYKED LEPDSPKEER
     SPHPATPAFP ITPKTPYTNL TSPIAHVPIG ITKTPLSELG LKPKPLELDD SKNIPGTHTP
     AGVHLSSAPK QHQVTSASIN GTTQGIMTQS QVTSPQQSVH MNKTTNRSVI VENSRIRLDE
     QTRPTNHQPT LESRDPSTQQ YIHGSFTPPL SQTTSYTATD RRPNGWQQNH SPHANSASPV
     ATKDMRSPWV FNGDTSPIAS SPAGKSPVIS SIASSATPPH GNGSGEVSPA GTRSLNGSND
     SLLSGGSASG HHPHLAYQKD RYSHNIPKDS SRHSASSIRS TSTGGSGYLG GASQTSPHSA
     GSPVSGSGQY PFTHINKRES QLSAYDRHGG HHLISSDEGG LSSPASGRTS ASSVSDIEKL
     AHEVSQANIA GTPPKFIKDT TAYWYKPEIN RDQAHAMLRT RPPGSFVVRA SRCYPGAFGL
     ALKVHQVPAA VLATAKPGTD MNNELVRHFL IEPSTRGVKL KGCPNEPVFG SLSALIYQHS
     ITPLALPCKL VIPTSNQDVP PAGSSRDSTE IQNSAVELLK QGAACNVLYL GSEDTESLTG
     PEAIERAMRE CMQNVGQAIK TSVVHFKVSP QGITLTDNAR KIFFRRHYPT ATVTYCGLDP
     SAREPHNRRW DASKDRGPPN ARVFGFVAKK PGSSVENVCH LFAELDLDQP APAIVNFVSK
     VLIGAAGSN
//
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