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Database: UniProt
Entry: F6V8X9_ORNAN
LinkDB: F6V8X9_ORNAN
Original site: F6V8X9_ORNAN 
ID   F6V8X9_ORNAN            Unreviewed;      1284 AA.
AC   F6V8X9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000023470, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000023470, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023470,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000023470}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023470};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000023470}.
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DR   STRING; 9258.ENSOANP00000023470; -.
DR   Ensembl; ENSOANT00000023474; ENSOANP00000023470; ENSOANG00000014912.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F6V8X9; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000014912; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     12     27       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     39     60       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    208    235       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    506    525       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    545    564       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    571    595       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    719    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    801    819       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    831    849       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    861    881       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    946       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1018   1044       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       10    114       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      249    501       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      505    644       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      664    751       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      800   1054       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1284 AA;  144040 MW;  CA5C74C8C068C9E9 CRC64;
     VRFVVMDPFT DLALTLCIVL NTLFMALEHY DMTPEFEDML YVGNLVFTGI FTAEMTFKVI
     ALDPYYYFQQ GWNIFDSIIV ILSLMELGLS RMGNLSVLRS FRLVLLPALL RPMPQGSAAR
     GSLGQTVEQL SPSILPQFLT PTAWLAPSAQ AHPDHLPWTH ARLRSAHLSG CPRGWGPHVF
     FRTLPLTPRP LCSFVYTIYY PIYFVNEVYI PLILFILLML YFCLPVLNLF LALLLSSFSA
     DSLSAPDEDG EMNNLQLAFA RIQRGFRALR RLCGHALHPP WSPATPGKLA APPSSGLLPD
     CVVPPCALPD PAPEPKSHRE TSTAVGAFQG QDSVLQPEDS VTDPNGAIRV PIAPGESDID
     DHEDEDSLHT DQESNQQFVA TLMGYPTWPA GSRGWLQCSL EGETDINTNR ATQREWEKRK
     SCDPNAQACG QRREDSYSEG STADLTNSVD LLEPLPGVGE DLQDPEDCFP EGCVQRCPCC
     VMDTTRCPGR VCWRLRKTCH RIVEHNWFES FIIFMILLSS GALAFEDIHL EGRKTVKAVL
     EYADLVFTYV FVLEMLLKWV AYGFQKYFTN AWCWLDFLIV DVSLISLVAN ALGYAEMGPI
     KSLRTLRALR PLRALSRFEG MRLMLSHTGR AHPRVGGVGF VTCCLEWNVA NAKGLMAPGP
     PFAQATFKGW MDIMYAAVDS RGECSHLSFT HNLPCPPTPL HHLHVYEEQP LWEHSLYMYL
     YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK
     PIPRPLNKYQ GFLFDIVTKQ AFDVTIMVLI CLNMVTMMVE TDDQSEGKTN ILAKINLLFV
     AIFTAECVVK MTALRHYYFT NSWNIFDFVV VILSIAGTVL SDIIQKYFFS PTLFRVIRLA
     RIGRVLRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FANVKWESGI
     DDMFNFQTFA NSMLCLFQIT TSAGWDGLLN PILNTGPPFC DPNVTNPNGS KGNCGSPAIG
     IVFFVTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEVW EKFDPEASQF
     IGYEALSDFA DALPEPLRVA KPNGIKLIHM DLPMVSGDRI HCMDILFAFT KRVLGESGEM
     DALKIQMEEK FMAANPSKVS YEPITTTLRR KHEEVSAIVI QRAFRSHLLR RSVKHASFLY
     RQQVGDGGVP GPDPPECRGL IADKMGENFS RQSSPTSSSF FPPSYDSITR ITGDRTQAQG
     SNSSGSGETG GLLTPWGGDR ESIV
//
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