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Database: UniProt
Entry: F6VC53_ORNAN
LinkDB: F6VC53_ORNAN
Original site: F6VC53_ORNAN 
ID   F6VC53_ORNAN            Unreviewed;       392 AA.
AC   F6VC53;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Selenide, water dikinase 1 {ECO:0000256|ARBA:ARBA00039825};
DE            EC=2.7.9.3 {ECO:0000256|ARBA:ARBA00011997};
DE   AltName: Full=Selenium donor protein 1 {ECO:0000256|ARBA:ARBA00042811};
DE   AltName: Full=Selenophosphate synthase 1 {ECO:0000256|ARBA:ARBA00042724};
GN   Name=SEPHS1 {ECO:0000313|Ensembl:ENSOANP00000024230.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024230.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000024230.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024230.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Synthesizes selenophosphate from selenide and ATP.
CC       {ECO:0000256|ARBA:ARBA00003786}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate +
CC         selenophosphate; Xref=Rhea:RHEA:18737, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:29317,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; EC=2.7.9.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001359};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004617}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004617}.
CC   -!- SIMILARITY: Belongs to the selenophosphate synthase 1 family. Class II
CC       subfamily. {ECO:0000256|ARBA:ARBA00038427}.
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DR   RefSeq; XP_001507943.1; XM_001507893.3.
DR   AlphaFoldDB; F6VC53; -.
DR   STRING; 9258.ENSOANP00000024230; -.
DR   Ensembl; ENSOANT00000024234.3; ENSOANP00000024230.2; ENSOANG00000015403.4.
DR   eggNOG; KOG3939; Eukaryota.
DR   GeneTree; ENSGT00390000000950; -.
DR   HOGENOM; CLU_032859_1_0_1; -.
DR   InParanoid; F6VC53; -.
DR   OMA; DNEPKYG; -.
DR   OrthoDB; 177624at2759; -.
DR   TreeFam; TF313811; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000015403; Expressed in fibroblast and 7 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004756; F:selenide, water dikinase activity; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0016260; P:selenocysteine biosynthetic process; IBA:GO_Central.
DR   CDD; cd02195; SelD; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004536; SPS/SelD.
DR   NCBIfam; TIGR00476; selD; 1.
DR   PANTHER; PTHR10256; SELENIDE, WATER DIKINASE; 1.
DR   PANTHER; PTHR10256:SF2; SELENIDE, WATER DIKINASE 1; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   PIRSF; PIRSF036407; Selenphspht_syn; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Selenium {ECO:0000256|ARBA:ARBA00023266};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          69..174
FT                   /note="PurM-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00586"
FT   DOMAIN          193..366
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   392 AA;  42907 MW;  E3F7DED52DE71F23 CRC64;
     MSVRESFNPE SYELDKSFRL TRFTELKGTG CKVPQDVLQK LLEALQENHF QEDEQFLGAV
     MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD
     NMLMLLGISN KMTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWI VLGGVATTVC
     QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA
     MMNMARLNRT AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA
     AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG
     NRTARIIDKP RIIEVAPQVA TQNVNPTPGA TS
//
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