ID F6VIR0_HORSE Unreviewed; 937 AA.
AC F6VIR0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=VPS50 subunit of EARP/GARPII complex {ECO:0000313|Ensembl:ENSECAP00000020625.2};
GN Name=VPS50 {ECO:0000313|Ensembl:ENSECAP00000020625.2,
GN ECO:0000313|VGNC:VGNC:24933};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020625.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020625.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020625.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020625.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020625.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6VIR0; -.
DR Ensembl; ENSECAT00000024807.3; ENSECAP00000020625.2; ENSECAG00000022811.4.
DR VGNC; VGNC:24933; VPS50.
DR GeneTree; ENSGT00390000003442; -.
DR HOGENOM; CLU_009513_1_0_1; -.
DR TreeFam; TF106152; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000022811; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6VIR0; baseline.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:1990745; C:EARP complex; IEA:InterPro.
DR GO; GO:0032456; P:endocytic recycling; IEA:InterPro.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR019514; Syndetin_C.
DR InterPro; IPR040047; VPS50.
DR InterPro; IPR019515; VPS54_N.
DR PANTHER; PTHR13258:SF0; SYNDETIN; 1.
DR PANTHER; PTHR13258; UNCHARACTERIZED; 1.
DR Pfam; PF10474; Syndetin_C; 1.
DR Pfam; PF10475; Vps54_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 54..345
FT /note="Vacuolar protein sorting-associated protein 54 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF10475"
FT DOMAIN 723..935
FT /note="Syndetin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10474"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 937 AA; 108321 MW; 242F19F1CC10F610 CRC64;
MQKIKSLMTR QGLKSPPESL SDLGAIESLR VPGKEEFREL REQPTDPQAE QELINSIEQV
YFSTDSFDIV KYELEKLPPV LNLQELEEYR DKLKQQQAAV SKKVADLILE KQPAYVKELE
RVTSLQTGLQ LAAVICTNGR RHLNIAKEGF TQASLGLLAN QRKRQLLIGL LKSLRTIKTL
QRTDVRLSEM LEEEDYPGAI QLCLECQKAA STFKHYSCIS ELNSKLQDTL EQIEEQLDVA
LSKICKNFDI NHYTKVQQAY RLLGKTQTAM DQLHMHFTQA IHNTVFQVVL GYVELCAGNT
DTKFQKLQYK DLCTHVTPDS YIPCLADLCK ALWEVMLSYY RTMEWHEKHD SEDTISASEG
SNMMGTEETN FDRGYIKKKL EHGLTRIWQD VQLKVKTYLL GTDLSIFKYD DFIFVLDIIS
RLMQVGEEFC GSKSEVLQES IRKQSVNYFK NYHRTRLDEL RMFLENETWE LCPVKSNFSI
LQLHEFKFME QSRSPSVSPS KQPASTSSKT VTLFEQYCSG GNPFEIQANH KDEETEDVLA
SNGYESDEQE KSAYQEYDSD SDVPEELKRD YVDEQTGDAP VKSVSRETLK SRKKSDYSLN
KVNAPILTNT TLNVIRLVGK YMQMMNILKP IAFDVIHFMS QLFDYYLYAI YTFFGRNDSL
ESTGLGLSSS RLRTTLNRIQ ESLIDLEVSA DPTSTLAAAE ERKEKVPSPH LSHLVVLTSG
DTLYGLAERV VATESLVFLA EQFEFLQPHL DAVMPAVKKP FLQQFYSQTV STASELRKPI
YWIVAGKAID YEQMLLLMAN VKWDVKEIMS QHNIYVDALL KEFEQFNRRL NEVSKRVWIP
LPVSNILWEH CIRLANRTIV EGYANVKKCS NEGRALMQLD FQQFLMKLEK LTDIRPIPDK
EFVETYIKAY YLTENDMERW IKEHREYSTK QLTNLWH
//
