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Database: UniProt
Entry: F6VLF2_HORSE
LinkDB: F6VLF2_HORSE
Original site: F6VLF2_HORSE 
ID   F6VLF2_HORSE            Unreviewed;       332 AA.
AC   F6VLF2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Hydroxycarboxylic acid receptor 1 {ECO:0000313|Ensembl:ENSECAP00000001042.3};
GN   Name=HCAR1 {ECO:0000313|Ensembl:ENSECAP00000001042.3,
GN   ECO:0000313|VGNC:VGNC:18705};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000001042.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000001042.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001042.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000001042.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001042.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   RefSeq; XP_014583086.1; XM_014727600.1.
DR   AlphaFoldDB; F6VLF2; -.
DR   STRING; 9796.ENSECAP00000001042; -.
DR   PaxDb; 9796-ENSECAP00000001042; -.
DR   Ensembl; ENSECAT00000001350.3; ENSECAP00000001042.3; ENSECAG00000001516.3.
DR   GeneID; 100060403; -.
DR   VGNC; VGNC:18705; HCAR1.
DR   GeneTree; ENSGT00990000203619; -.
DR   HOGENOM; CLU_009579_8_2_1; -.
DR   InParanoid; F6VLF2; -.
DR   OMA; RHRQWAF; -.
DR   TreeFam; TF330775; -.
DR   Proteomes; UP000002281; Chromosome 8.
DR   Bgee; ENSECAG00000001516; Expressed in leukocyte and 20 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR   CDD; cd15201; 7tmA_HCAR1-3; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR46048:SF3; HYDROXYCARBOXYLIC ACID RECEPTOR 1; 1.
DR   PANTHER; PTHR46048; HYDROXYCARBOXYLIC ACID RECEPTOR 2; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..278
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   332 AA;  37979 MW;  75FC0F36E8278E72 CRC64;
     MDNESCCLIE GDPIPQVMPP LLILAFVLGA LGNGIALYGF CFHMKTWKPS TIYLFNLAVA
     DFLLMVCLPF RTDYYLRHRQ WAFEDIPCRV VLFMMATNRA GSIVFLTVVA VDRYFKVVHP
     HHMMNTISNR TAAGIVCALW TMIILGTLYL LMEKHLCVQG ETVSCESFIM ESANGWHDVM
     FQLEFFLPLG IILFCSFKII WSLKQRQHLA RQTRMKKATR FIMVVAAVFV TCYLPSVSAR
     LYFLWTVPLS ACDPSVHIAL HVTLSFTYMN SMLDPLVYYF SSPLFPKFYA KLKIGSLRPK
     RPGRSKTRRP EEMPVSSLCH RSCTSVTNSF QS
//
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