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Database: UniProt
Entry: F6VM10_HORSE
LinkDB: F6VM10_HORSE
Original site: F6VM10_HORSE 
ID   F6VM10_HORSE            Unreviewed;      4851 AA.
AC   F6VM10;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013008};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013008};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013008, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013008, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013008,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013008}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013008};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013008}.
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DR   STRING; 9796.ENSECAP00000013008; -.
DR   PaxDb; F6VM10; -.
DR   Ensembl; ENSECAT00000016127; ENSECAP00000013008; ENSECAG00000013267.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; HDECLTI; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; -.
DR   ExpressionAtlas; F6VM10; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4164   4188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4392   4412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4460   4479       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4591   4609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4652   4673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4732   4755       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1191       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3899   3934       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4851 AA;  550200 MW;  4D2690A12CBD4DA7 CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEIK EKLDSSHKRD IEGMGVPEIK YGDSVCFVQH VSSGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TTAPVTLPIE
     EVLQTLQDLI AYFQPPEEEM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIARE ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VVSFSAGVKV RFLMGGRHGE
     FKFLPPTGYA PCYEALLPKE KMRLEPVKEY KRDAEGVRDL LGTTQFLSQA SFIPCPIDTS
     QVVLPPHLEK IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN
     YNLQMSTETL KTLLALGCHI AHVNPAAEED LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP
     PQEILVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL
     REAVRTFVGY GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG
     DMRVGWARPG CRPDVELGAD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA
     SMIFTLNGEL LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGMDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG
     TQNSNANMIY CRLSMPVECH ASFSHSPCLD SDAFQKRKQM QEILSHTTTQ CYYTIRIFAG
     QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV TVTLGDERGR VHESVKRSNC YMVWGGDIVA
     TSQRSSRSNV DLEIGCLVDL AMGMLSFSAN GRELGTCYQV EPNTKVFPAV FLQPTSTALF
     QFELGKLKNA MPLSAAIFKS EEKNPVPQCP PRLDIQTIQP VLWSRMPNSF LKVETERVSE
     RHGWVVQCLE PLQMMALHIP EENRCVDILE LCEQEDLMLF HYHTLRLYSA VCALGNSRVA
     YALCSHVDLS QLFYAIDNKY LPGLLRSGFY DLLISIHLAS AKERKQMMKN EYIIPITSST
     GKIRLYPDES KRHGLPGVGL RTCLKPGFRF STPCFVVTSE EHQKQSPEIP LEILKTKALS
     MLTEAVQCSG AHIRDPVGGS VEFQFVPVLK LIGTLLVMGV FDDDSVRQIL LLIDPSVFGE
     HSGEMEEGAE KEEVTQVEEK AVEAGEKASK EAPVKGLLQT RLPESVKLQM CELLSYLCDC
     ELQHRVEAIV AFGDIYVSKL QANQKFRYNE LMQALNMSAA LTARKTREFR SPPQEQINML
     LNFQLGENCP CPEEIREELY DFHEDLLIHC GVPLEEEEEE EEDTSWTGKL RALVYKIKGP
     PKPEKELPTE EEERCPTTLK ELISQTMIRW AQEDQIQDAE LVRMMFNLLR RQYDSIGELL
     QALRKTYTIS QASVSDTINL LAALGQIRCL LSVRMGKEEE LLMINGLGEI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GAEKSQIAFP KMVASCCRFL CYFCRISRQN QKAMFEHLSY
     LLENSSVGLA SPSMRGFTPL DVAASSVMDN NELALGLEEP DLEKVVTYLA GCGLQSCPML
     LAKGYPDVGW NPIEGERYLS FLRFAVFVNS ESVEENASVV VKLLIRRPEC FGPALRGEGG
     NGLLAAMQGA IKISENPALD LPSQGYKREV STEDAEDDEI VHMGNAIMSF YSALIDLLGR
     CAPEMHLIQT GKGEAIRIRS ILRSLVPTED LVGIISIPLK LPSLNKDGSV SEPDMAANFC
     PDHKAPMVLF LDRVYGIKDQ TFLLHLLEVG FLPDLRASAS LDTVSLSTTE AALALNRYLC
     SAVLPLLTRC APLFAGTEHY TSLIDSTLQT IYRLSKGRSL TKAQRDTIEE CLLAICNHLR
     PSMLQQLLRR LVFDVPQLNE YCKMPLKLLT NHYEQCWKYY CLPSGWGSYG LAVEEELHLT
     EKLFWGIFDS LSHKKYDQDL FRMALPCLSA IAGALPPDYL DTRISATLEK QVSVDADGNF
     DPKPINTVNF SLPEKLEYIV TKYAEHSHDK WACDKSMQRW KYGISLDENV KTHPLIRPFT
     LTEKEKEIYR WPARESLKTM LAVGWTIERT KEGEALVQQR ENEKLRSVSQ ASQGNSYSPA
     PLDLSNVVLS RELQGMVEVV AENYHNIWAK KKKLELESKG GGSHPLLVPY DTLTAKEKFR
     DREKAQDLFK FLQVNGIVVS RGMKDMELDA SSMEKRFAYK FLKKILKYVD SAQEFIAHLE
     AIVSSGKTEK SPHDQEIKFF AKVLLPLVDQ YFTNHRLYFL SSPLKPLSSS GYASHKEKEM
     VASLFCKLAA LVRHRISLFG NDSTTMVSCL HILAQTLDTR TVMKSGSELV KAGLRAFFEN
     AAEDLEKTSE NLKLGKFTHS RTQIKGVSQN INYTTVALLP ILTSIFEHVA QHQFGVDLLL
     GDVQISCYHI LCSLYSLGTG KNIYVERQRP ALGECLASLA AAIPVAFLEP TLNRYNPLSV
     FNTKTPRERS ILGMPDTVEE MCPDVPQLEG LMKEINDLAE SGARYTEMPH VIEVILPMLC
     NYLSYWWERG PEHLPPSTGP WCTKVTSEHL SVTLGNILKI INNNLGIDEA SWMKRIAVYA
     QPIISKARPG LLRSHFLPTL EKLKKKAVKT VQEEEQLKAD SKGDTQEAEL LILDEFAVLC
     RDLYAFYPML IRYVDNNRSN WLKSPDAYSD QLFRMVAEIF ILWCKSHNFK REEQNFVIQN
     EINNLAFLTG DSKSKMSKAM QVKSGGQDQE RKKTKRRGDL YSIQTSLIVA ALKKMLPIGL
     NMCTPGDQEL ISLAKSRYSY KDTDEEVKEH LRNNLHLQEK SDDPAVKWQL NLYKDVLKSE
     EPSNPEKTVE RVQRISAAVF HLEQVEQPLR SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL
     PHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE EEEEETEKQP DPLHQIILHF
     SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEEEEEEEDK EKTFEEKEME KQKTLYQQAR
     LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN AGVQQKMLDY LKEKKDAGFF
     QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE RGEKILQNDE FTRDLFRFLQ
     LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH
     NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ
     IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV ESSTNVEMIL KFFDMFLKLK
     DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG QKQYIQSEID FLLSCAEADE NDMFNYIDFV
     DRFHEPAKDI GFNVAVLLTN LSEHMPNDSR LKSLLDPAES VLNYFEPYLG RIEIMGGAKK
     IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS
     QISESDSADR PEEEEQAEED SSYMLEIEGE EEDDRSFESV SAFAMACASV RRNVANFLKR
     ATLKNLRKQY RKVKKMTVKE LVKVFFSFFW TLFVGLFQLF FTILGGIFQI LWNTVFGGGL
     VEGAKNIRVT KILGDMPDPT QFGIHDDALE AERAEVTEPG IATELVYFVK GEKGDADIMS
     DLFGYHSKKE SGLKHGPEVG LGDLSEIIGK DEPPTLESAV QKKRKAQAAE MKAAHEAEGK
     VESEKADMED GEKEDTAKEE VQAEALWAEA TKKKKRRCGQ KVEKPEAFMA NFFKGLEIYQ
     TKLLHYLARN FYNLRFLALF VAFAINFILL FYKVTEEPLE EETEDVANLW NSFNDEEEEE
     AMVFFVLQES TGYMAPTLRA LAIIHTIISL VCVVGYYCLK VPLVVFKREK EIARKLEFDG
     LYITEQPSED DIKGQWDRLV INTPSFPNNY WDKFVKRKVI NKYGDLYGAE RIAELLGLDK
     SALDFSPVEE TKAEAASLVS WLSSIDMKYH IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN
     FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS
     EDDDEPDMKC DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DPYEMYRIVF DITFFFFVIV
     ILLAIIQGLI IDAFGELRDQ QEQVREDMET KCFICGIGND YFDTTPHGFE THTLQEHNLA
     NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE RCWDFFPAGD CFRKQYEDQL G
//
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