ID F6VQ95_XENTR Unreviewed; 1283 AA.
AC F6VQ95;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSXETP00000045015};
GN Name=ttc21b {ECO:0000313|Ensembl:ENSXETP00000045015};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000045015};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000045015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000045015};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000045015}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TTC21 family.
CC {ECO:0000256|ARBA:ARBA00010935}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PaxDb; 8364-ENSXETP00000055490; -.
DR Ensembl; ENSXETT00000045015; ENSXETP00000045015; ENSXETG00000020844.
DR AGR; Xenbase:XB-GENE-6047950; -.
DR Xenbase; XB-GENE-6047950; ttc21b.
DR eggNOG; ENOG502QQAB; Eukaryota.
DR HOGENOM; CLU_006149_0_0_1; -.
DR TreeFam; TF314664; -.
DR Bgee; ENSXETG00000020844; Expressed in brain and 13 other cell types or tissues.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR040364; TTC21A/TTC21B.
DR PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR Pfam; PF14559; TPR_19; 2.
DR Pfam; PF07719; TPR_2; 1.
DR Pfam; PF13174; TPR_6; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 16.
DR SUPFAM; SSF48452; TPR-like; 6.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 291..324
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 689..722
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 919..952
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1233..1266
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 1283 AA; 146603 MW; 58D29754629D8D67 CRC64;
MATEAALASA QALINYYCQE KYFHHVQMCA NEGLKDYGND PVFLFFRAFG MLMEDREAIQ
ELDSKMKELR KTAGHRGLYF SGLFLWHVGR HDKAREYIDR MIKISNGSKE GLVLKAWLDL
TCGREAYAKK ALKYLEEGLA DGTDVFAMLG KAHYLEMRQN YSEALEVINR ILVHCPGFIP
ALIKKMKLQL ALQDWEQTVE TALRLLQKDS HNLEALRMLA LHYLCREGNV HEASTKLGDL
IRALDQFEPQ NAHLYYNMSL AFSRMCERNP LILQQTQTLV ERAVNMAAND AEIATELGYQ
FILQGKVREA LKWYKTAMSL DETSVSALTG IIRCQLIEGQ LQDADQQLEF LMEIQQSIGK
SGELSYLRAV LAMKKQKKQE EVIHLLNDVL DTHFSSLHGL PLGIQYFEKL NPDFLLEIVR
EYLSFCPTQP STPGQPVSPL LRHCASVLEA IMKTAPGLQQ AAFLIAKVKY LSGDIDAAQN
SLQHCLDQNP SYADAHLLMS QIYLFQDNLK LCSQSLELCL SYSFEIRDYP LYNLIKAQTQ
KRMGEVQEAI KTLQIAMSLP GMRRAGTSVK SKGKKPEVSP SDRVSIFLEL VDAHRLNGEQ
HEATKVLQDA IIEFSGTPEE LRLMIANAEL ALVHGDVEEA LSMLRNVSPE QPYFVQAKEK
MAEIYLKHRK DKKLYVSCYR DLVDKLPSSH TYLLLGDAYM NIQEPEKAIE IYEQALKKNP
KDGTLASKIG KALIKTHNYS KAISYYEAAL KSGQQSFLRY DLAELLLRLK QYDKAEKVLQ
QALDHEAVNE LSSLMDDSRY HVLLAKIYSK MEKIDDSIVS LQRARELQAR VLKRTQMEQP
DAVPAQKALA AEICAEIAKH STVQRDYEKA IKFYKEALVY CETDNKVMLE LAHLYLAQDD
TESCQQQCAL LLKIDQDNEA ATMMMADLMF RKQDYEQAVF HFQQLLERKP DNYATLSRLI
DLLRRAGKLE EIPKFLELAE KNSPRAKLEP GFHYCNGLYL WYTGDPNDAL RHFNKARKDS
DWGQNAIYNM IEICLNPDNE TVGGEVFDNL DGDVGNSTEK QESVQLAVRT AEKLLKELKP
QTLQGHIQLR IMENYCLMAT KQKANVERAL NTFTEVATAE KDHIPALLGM ATAYMILKQT
PKARNQLKRI SKMNWNPIDA EEFEKGWLLL ADIYIQSGKY DMAGELLKRC LRHNRSCCKA
YEYTGYIMEK EQAYKDAASN YEMAWKYGNQ TSPTVGYKLA FNYLKAKRYV DAIDVCHKVL
ELHPNYPKIR KDILDKSRAA LRA
//
