ID F6VRU3_XENTR Unreviewed; 1014 AA.
AC F6VRU3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6 {ECO:0000313|Ensembl:ENSXETP00000000722};
GN Name=herc6 {ECO:0000313|Ensembl:ENSXETP00000000722};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000000722};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000000722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000000722};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000000722}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR AlphaFoldDB; F6VRU3; -.
DR Ensembl; ENSXETT00000000722; ENSXETP00000000722; ENSXETG00000000342.
DR AGR; Xenbase:XB-GENE-968556; -.
DR Xenbase; XB-GENE-968556; herc6.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_3_1; -.
DR PhylomeDB; F6VRU3; -.
DR TreeFam; TF315189; -.
DR Bgee; ENSXETG00000000342; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF58; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 5.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 37..86
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 87..139
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 140..192
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 193..247
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 248..298
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 689..1014
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 982
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1014 AA; 113189 MW; 6C5DBA80F159859C CRC64;
MYFFPKESKA KRTKKTQECV QKVSCGEKHT LYLLEDGTLL SCGQNPYGQL GRKSNNSSIE
QISSLEAQTI VDISCGTNHS VAVSDEGSIY SWGDGSEGQL GTGNLSSRNF TPKKITGLFN
TKIIQISCGN FHSLALSEDG RVFSWGQNKC GQLGLGSQII NQATPQLVKS LKGIPLVQVT
AGGSQSFALS MSGTVFAWGK NNAGQLGFKS DPMKAGTFKP HAVNSLRNLG VAYISCGEEH
TAVLSKDGSV YTFGDDTHGQ LGQNSGNQTS VPQKIEDYAG QVSQVACGRY HTLLYVFSCN
RIVSFGKGSL RPQDNTECSD EAELPSEFDI SSLVPTNDLR DVYVKWIFAG NNVGFAVPFS
QQEATKRTLL SDTFKPILRL DLPTIKKWMK AQTGSEEYQI AKREICTIFS SPACFTAGFV
NRSSSNTSSA SSIVDLGVAS KLFTELIKDR RISDIICSSI RNDLIPELES LPLLYEAFAI
FLLLPECPLL HDLSICLSVV VALAKAINNM GESSLKILGT LWSHMQASSM TKQIQLLKIA
VILSIQGIQA EPGTKDLLQM LKKLYKANLK GNCIVPINAF CMNELCPLII LPLDVNNWRL
WQSQPEPDEN AFPAIYCRFP FVFNFPTKVQ ALHLDSMRKR NNEKFQAQEQ LVRNRLQGIS
DLPNIPLLHL ILRRGHLLED TLHKLSIVED PNLKKDLLVE FQGESTTDSA AVTKEFFLVL
LESMVNPDYG MFSCSDPLLP IWFPSTPLVE KKKYFYFGII CGLAVYNQIV IYLPFPLALF
KKLLGKKATL EDLKELQPTM GRTMKDLLDA ESTVVESMET YFCFSWDNKS IDLIPNGGSV
QVNNLNKKDF VNKCIDYIFN TSVMVPFEEF KRGFYKVCDK EIISFFQPDE LMALVAGTTE
YDWNIFEKTT MYLGKFTPDH PTIRMFWKVF HALSLVNKKG FLMFLTGNDK LPIFTRGGDN
IRMKISSFGV PDETHLPEAQ TCFHMLFLPE YSNIKSLKQK LMLAIAHNKG YEKI
//
