ID F6VSJ2_HORSE Unreviewed; 1540 AA.
AC F6VSJ2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 {ECO:0000313|Ensembl:ENSECAP00000020390.4};
GN Name=ARHGEF12 {ECO:0000313|VGNC:VGNC:15484};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020390.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020390.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020390.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020390.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020390.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSECAT00000024539.4; ENSECAP00000020390.4; ENSECAG00000022702.4.
DR VGNC; VGNC:15484; ARHGEF12.
DR GeneTree; ENSGT00940000157662; -.
DR HOGENOM; CLU_003962_1_1_1; -.
DR TreeFam; TF106495; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000022702; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; F6VSJ2; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13390; PH_LARG; 1.
DR CDD; cd08754; RGS_LARG; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR037801; ARHGEF12_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037884; LARG_RGS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 53..132
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 783..973
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1015..1128
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 202..255
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1540 AA; 172349 MW; 3F168D807687A08C CRC64;
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSA SHDFDPTGLV QRCVIIQKDD
NGFGLTVSGD NPVFVQSVKE GKALFKTVSS LGSKQNGAAM RAGVQTGDRI IKVNGTLVTH
SNHLEVVKLI KSGSYVALTV QGRPPGSPQI PLADSEVEPS VIGHMSPIMT SPHSPGASGN
MERITSPVLM GEENNVVHNQ KVEILRKMLQ KEQERLQLLQ EDYNRTPAQR LLKEIQEAKK
HIPQLQEQLS KATGSAQDGA VVTSSKPLGD ALTVSEVEAD PGDGLGRIDY SSGDVSRHSS
DNADSPKSGL KERIYLEENP EKSEVNQDID TQSLIGSPST RIAPHIIGAE DDDFGTEHEQ
INGQCSCFQS IELLKSRPAH LAVFLHHVVS QFDPATLLCY LYSDLYKQTN SKETRRVFLE
FHQFFLDRSA HLKVSVPDEI SVDLDKRRPE LIPEDLHRHY IQTMQEKVHP EVQRHLEDFR
QKRSMGLTLA ESELTKLDAE RDKDRVTLEK ERACAEQIVA KIEEVLMTAQ AVEEDKSSTM
QYVILMYMKH LGVKVKEPRN LEHKRGRIGF LPKIKQSMKK DREGEEKGKR RGFPSILGPP
RRPSRHDNSA IGRAMELQKQ RHPKHLSTPS SVSPEPQDPA KLRQSGLASE GADAGYLPAN
STSSVVSGAT LSQEGGKEND TGSKQVGETP TSGDSLDGTP RTPNTIFDFP PPPLDQVQEE
EWEVERVTEH GTPKPFRKFD SIAFGESQSE DEQFENDLET DPPNWQQLVS REVLLGLKPC
EIKRQEVINE LFYTERAHVR TLKVLDQVFY QRVSREGILS PSELRKIFSN LEDILQLHIG
LNEQMKSVRK RNETSVIDQI GEDLLTWFSG PGEEKLKHAA ATFCSNQPFA LEMIKSRQKK
DSRFQTFVQD AESNPLCRRL QLKDIIPTQM QRLTKYPLLL DNIAKYTEWP MEREKVKKAA
DHCRQILNYV NQAVKEAENK QRLEDYQRRL DTSNLKLSEY PNVEELRNLD LTKRKMIHEG
PLVWKVNRDK TIDLYTLLLD DILVLLQKQD DRLVLRCHSK ILASTADSKH TFSPVIKLNT
VLVRQVATDN KALFVISMSD NGAQIYELVA QTVSEKTVWQ DLICRMAASV KEQSTRPIPL
PESPPCEGDN DEEEPPKLKV EHHGISVTGL QSPDRDLGLE SPLISSKPQS HSLGASGKSE
VDDLFVAERQ FAKEQRADGT LKEVGGNYQI TIPNPHLPVS EERWALDALR NLGLLKQLLV
QQLGLTEKST QEDWPHFPRY RTASPGAQAD SGTQNSETLK AYHPGEGQMP FRTGTGDISS
CYGPRTSTES SAPQDSVVLA FQDGQASNIL VMDHVIMTPE MPPAEPEGGL DESGEHFFDA
REAHSDDNPS DGDGAVKKEE KDVNLRISGN YLILDGYETV QESSTDEEIA SSLPSQPVTG
IPSVDCTHQR QHSPQNARSD GAVSPFTPEF LVQQRWGAME DSCFEIQSPP SCADSQSQIM
EYIHKIEADL EHLKKVEESY TILCQRLAGS ALTDKHSDKS
//
