ID F6VZM1_HORSE Unreviewed; 2427 AA.
AC F6VZM1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1H {ECO:0000313|Ensembl:ENSECAP00000020369.3,
GN ECO:0000313|VGNC:VGNC:51118};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020369.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020369.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020369.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020369.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020369.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. This channel gives rise to T-type calcium
CC currents. T-type calcium channels belong to the "low-voltage activated
CC (LVA)" group and are strongly blocked by nickel and mibefradil. A
CC particularity of this type of channels is an opening at quite negative
CC potentials, and a voltage-dependent inactivation. T-type channels serve
CC pacemaking functions in both central neurons and cardiac nodal cells
CC and support calcium signaling in secretory cells and vascular smooth
CC muscle. They may also be involved in the modulation of firing patterns
CC of neurons which is important for information processing as well as in
CC cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 9796.ENSECAP00000020369; -.
DR PaxDb; 9796-ENSECAP00000020369; -.
DR Ensembl; ENSECAT00000024516.4; ENSECAP00000020369.3; ENSECAG00000022241.4.
DR VGNC; VGNC:51118; CACNA1H.
DR GeneTree; ENSGT00940000156666; -.
DR InParanoid; F6VZM1; -.
DR OMA; RCLIAVY; -.
DR OrthoDB; 1110761at2759; -.
DR TreeFam; TF313555; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000022241; Expressed in synovial membrane of synovial joint and 15 other cell types or tissues.
DR ExpressionAtlas; F6VZM1; baseline.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IBA:GO_Central.
DR GO; GO:0008332; F:low voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR GO; GO:0032342; P:aldosterone biosynthetic process; IEA:Ensembl.
DR GO; GO:0070509; P:calcium ion import; IBA:GO_Central.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR GO; GO:0035865; P:cellular response to potassium ion; IEA:Ensembl.
DR GO; GO:0034651; P:cortisol biosynthetic process; IEA:Ensembl.
DR GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; IEA:Ensembl.
DR GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1340..1361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1373..1402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1437..1456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1564..1586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1606..1630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1692..1709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1729..1748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1827..1847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1859..1879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1914..1935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..429
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 790..1018
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1300..1640
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1692..1945
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2050..2325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2342..2427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2219..2258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 378
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 971
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1579
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2427 AA; 266435 MW; 9DAD7D3FCBBADBC4 CRC64;
MTEGALAAGE VRVPLGAPAP GPAAAGASPA SPGAPGREAE RGSGPGTSPP ESPAAERGAE
LGADEEQPVP YPALAATVFF CLGQTTRPRS WCLRLVCNPW FEHVSMLVIM LNCVTLGMFR
PCEDVECRSE RCSILEAFDD FIFAFFAVEM VIKMIALGLF GQKCYLGDTW NRLDFFIVMA
GMMEYSLDGH NVSLSAIRTV RVLRPLRAIN RVPSMRILVT LLLDTLPMLG NVLLLCFFVF
FIFGIVGVQL WAGLLRNRCF LDSTFARNNN LTFLRPYYQT EEGEENPFIC SSRRDNGMQK
CSHIPSRREL RVECTLGWEA YGQPQAEGAG GAGRNACINW NQYYNVCRSG DSNPHNGAIN
FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI LLIIVGSFFM INLCLVVIAT
QFSETKQREN QLMREQRARY LSNDSTLASF SEPGSCYEEL LKYVGHIYRK VKRRSLRLYA
RWQSRWHKKV DPSSALHGQG PGRRPRRPGR RAASIHHLVY HHHHHHHHHY HFSHGSPRRP
GHEPATGDTR LVRAGALPSP PSPGRGPPDT ESVHSVYHAD CHVEGPQERA RAVHAAATAA
GLKLATGLGA MNYPTILPSP AGGKGGASPG PKGKRASGPP GAGNHSPLSL SSSDPYEKIQ
HLVGEHGLGR SPSRLSGLSV PCPLPSPQAG TLTCELKNCP YCASALEDPE VELSDSEGGD
SDSNAVYEFT QDVQHGDRRD PMQPPPAADA PGQGGPRRRA QRQAAPGEQG GLGRVWATFS
GKLRRIVDSK YFNRGIMVAI LTNTLSMGVE YHEQPDELTN ALEISNIVFT SMFALEMLLK
LLACGPLGYI RNPYNIFDGI IVIISVWEII GQADGGLSVL RTFRLLRVLK LVRFMPALRR
QLVVLMKTMD NVATFCMLLM LFIFIFSILG MHLFGCKFSL KTDTGDTVPD RKNFDSLLWA
IVTVFQILTQ EDWNVVLYNG MASTSSWAAL YFVALMTFGN YVLFNLLVAI LVEGFQAEGD
ANRSDTDEEK TSARLEEDFD KFRDLRATEM KMYSLAVTPN GHLEGRGSLP PPLIMRTAAT
PMPTPKSSPH LDVAHGLLDS RRGSSCSMDP QLGDQKSLSS LRSSPCTQLG PNSAWSSRRS
SWNSLGRAPS LKRRSQCGER ESLLSGEGKG STDDEAEDSR PGAGTSPGTC ATPLRRTESL
DRRSTLDLRP PRPAALLPSK FHDCNGQVLA LPSEFFLRID SHKEDPAEFD DDMEDSCCSR
LRKVLEPYEP EWCRRRDPWA LYLFSPQNRF RLSCQKIIAH KLFDHVVLVF IFLNCITIAL
ERPDIDPGST ERAFLSVSNY IFTAIFVAEM TVKVVALGLV SGEHTYLQSS WNVLDGLLVL
VSLVDIVVAM ASAGGAKILG ILRVLRLLRT LRPLRVISRA PGLKLVVETL ISSLRPIGNI
VLICCAFFII FGILGVQVRS PACPWVSPPW EVVSGRQLHG SPRRAEGGAG GETPVSAVLP
LEASRAGLGS RGSGPGLWVT GRPAQLFKGK FYYCEGADTR NISTKAECRA AHYRWVRRKY
NFDNLGQALM SLFVLSSKDG WVNIMYDGLD AVGIDQQPVP NHNPWMLLYF ISFLLIVSFF
VLNMFVGVVV ENFHKCRQHQ EAEEARRREE KRRRRLERKR RSTFPNPEAQ RRPYYADYSP
ARRSIHSLCT SHYLDLFITF IIGVNVITMS VEHYNQPKSL DEALKYCNYV FTIVFVLEAV
LKLVAFGFRR FFKDRWNQLD LAIVLLSIMG ITLEEIEMNA ALPINPTIIR IMRVLRIARV
LKLLKMATGM RALLDTVVQA LPQVGNLGLL FMLLFFIYAA LGVELFGRLE CSEDNPCEGL
SRHATFSNFG MAFLTLFRVS TGDNWNGIMK DTLRECARED KHCLSYLPAV SPVYFVTFVL
VAQFVLVNVV VAVLMKHLEE SNKEAHEDAE LDAELELEMA QGSPTHPQPV AQPSPGAGPD
APSLLVVRKV SVSRMLSLPN DSYMFRPVAP ASAPHPHRLQ EVEMETYVGS APLGLVASAH
SPPAESCAAL QVPSAASSPA RSSDRLHALP PHGIARSPSL SRLLCRQEAV PTDSLEGQVD
SPRDSGPGWG EPGGKTPVRQ ASLGASLRTP PRSPRPPGIR IRRHTLGQRC VSSQPPAPSG
EEAEAPDPAD EEVSHITSSA RSPSASPSPT PTARGVAGSE PDPHRLYGVD TQGFLDQPGR
ADEQRRPPVE QGSGDGRPEA GEGKARALEA ELALGARRKK KMSPPCISVD PPAEEEGTAR
PPAAEGGSTT LRRRTPSCEA APHRDSLEPT EGPGVDPAAK GERWGQASCR TELLTVPSFV
FDAPLGVGGT GGDLFLDGGH DVSPEPRGSS SGATALPEPH RTEPPMSSGD PPEKGQGLHL
QVPQSPPKKE GSPPGTPIPG DSVDEPV
//
