ID F6W1E0_XENTR Unreviewed; 455 AA.
AC F6W1E0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Monocarboxylate transporter 6 {ECO:0000313|RefSeq:XP_002940018.3, ECO:0000313|RefSeq:XP_012808406.2};
DE SubName: Full=Solute carrier family 16 (monocarboxylate transporter), member 5 {ECO:0000313|Ensembl:ENSXETP00000027347};
GN Name=slc16a5 {ECO:0000313|Ensembl:ENSXETP00000027347,
GN ECO:0000313|RefSeq:XP_002940018.3, ECO:0000313|RefSeq:XP_012808406.2,
GN ECO:0000313|RefSeq:XP_031750180.1, ECO:0000313|RefSeq:XP_031750181.1,
GN ECO:0000313|Xenbase:XB-GENE-1008043};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000027347};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000027347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000027347};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000027347}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002940018.3, ECO:0000313|RefSeq:XP_012808406.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002940018.3,
RC ECO:0000313|RefSeq:XP_012808406.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002940018.3,
RC ECO:0000313|RefSeq:XP_012808406.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_002940018.3; XM_002939972.5.
DR RefSeq; XP_012808406.2; XM_012952952.3.
DR RefSeq; XP_031750180.1; XM_031894320.1.
DR RefSeq; XP_031750181.1; XM_031894321.1.
DR Ensembl; ENSXETT00000027347; ENSXETP00000027347; ENSXETG00000012500.
DR Ensembl; ENSXETT00000117881; ENSXETP00000106059; ENSXETG00000012500.
DR Ensembl; ENSXETT00000119009; ENSXETP00000116874; ENSXETG00000012500.
DR KEGG; xtr:100485544; -.
DR AGR; Xenbase:XB-GENE-1008043; -.
DR Xenbase; XB-GENE-1008043; slc16a5.
DR eggNOG; KOG2504; Eukaryota.
DR HOGENOM; CLU_001265_59_1_1; -.
DR OMA; TWGAYQT; -.
DR OrthoDB; 2917104at2759; -.
DR TreeFam; TF313792; -.
DR Reactome; R-XTR-212436; Generic Transcription Pathway.
DR Proteomes; UP000008143; Chromosome 10.
DR Bgee; ENSXETG00000012500; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17425; MFS_MCT6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360; MONOCARBOXYLATE TRANSPORTER; 1.
DR PANTHER; PTHR11360:SF21; MONOCARBOXYLATE TRANSPORTER 6; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..455
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117489"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..423
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 455 AA; 49618 MW; C577F66D3379C0B9 CRC64;
METPDGPWAW VVLAAVMLTQ GLSLGFPSCI GIFYTDIQTS FQASNTETSW FPSIIMAVLH
AGGPLCTIMV ERFGCRVTVM VGGLLCGVGM VTSAFSQTII HLYLSAGFVG GLGFCFCFQA
GITVLGYYFI RRRTLANSLA SAGASIGMAL WPLASQHLLE TMGWRGSFLL FGGVLLNCCV
CGAIMRPVRS LEPAHEKEVL APEEPNGIKH KGEKTEQGKG LQRYMAFDLL FRHRRYQIYA
LGVTWMVLGF VLPLFYLVPY ATSNDIDEKK AALLLSLVGF MNIFMRPMAG LVSQQKVFHG
RLMYLFSVAV ILNGLSNLVC AIWVSFPALL TYCVLYSITM SFIGSLIFQV LMDTVGMKRF
PGAFGLFTIL ESITIMAGPP LAGLLVDITG QYGLVFYASS IAVTSSGLFM GLASFAVDRS
EAKARRCSQR PTEATDNKDN GDAIYSPCKQ EDCIL
//
