ID F6W616_ORNAN Unreviewed; 418 AA.
AC F6W616;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Tripartite motif containing 13 {ECO:0000313|Ensembl:ENSOANP00000024477.3};
GN Name=TRIM13 {ECO:0000313|Ensembl:ENSOANP00000024477.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024477.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000024477.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024477.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000024477.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024477.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR RefSeq; XP_007666767.1; XM_007668577.2.
DR RefSeq; XP_007666772.1; XM_007668582.2.
DR RefSeq; XP_007666773.1; XM_007668583.2.
DR RefSeq; XP_016083121.1; XM_016227635.1.
DR RefSeq; XP_016083122.1; XM_016227636.1.
DR AlphaFoldDB; F6W616; -.
DR Ensembl; ENSOANT00000024481.3; ENSOANP00000024477.3; ENSOANG00000015539.3.
DR GeneID; 100083143; -.
DR CTD; 10206; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000159715; -.
DR HOGENOM; CLU_053708_0_0_1; -.
DR OrthoDB; 5383069at2759; -.
DR TreeFam; TF331669; -.
DR Proteomes; UP000002279; Chromosome 20.
DR Bgee; ENSOANG00000015539; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19767; Bbox2_TRIM13_C-XI; 1.
DR CDD; cd16762; RING-HC_TRIM13_C-V; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF609; E3 UBIQUITIN-PROTEIN LIGASE TRIM13; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 20..67
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
FT DOMAIN 99..141
FT /note="B box-type"
FT /evidence="ECO:0000259|SMART:SM00336"
SQ SEQUENCE 418 AA; 47477 MW; 95F037135FBE1708 CRC64;
MTAHLTCLDV MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILDG NVRNMLWRSA
PFKCPTCRKE VSATGVSSLQ VNYSLKGIVE KYNKIKVSPK MPVCKGHVGQ PLNIFCLTDM
QLICGVCATR GEHTKHVFCS IEDAYAQERN AFESLFQGFE TWRRGDALSR LDSLETGKRK
SLQLLTKDSD KVKEFFEKLL YTLEQKKNEI LSDFETMKLE VMQAYDPEIN KLNTILQEQR
MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPSS NLPASPMLIN FDTSHWEGIK
LVDVDKLSLP QEASNFISKI PRSFQQIFVA VSLLGLLLFF TPSMSSDGSL FDSLLVWKGY
ISSIGSCYLT ESTEIANKAV AYWEQMSEGI FLLTESCKSY SFVVLNSVAE FVCRYKLL
//
