GenomeNet

Database: UniProt
Entry: F6W6M3_ORNAN
LinkDB: F6W6M3_ORNAN
Original site: F6W6M3_ORNAN 
ID   F6W6M3_ORNAN            Unreviewed;       547 AA.
AC   F6W6M3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Ankyrin repeat domain 13C {ECO:0000313|Ensembl:ENSOANP00000024465.2};
GN   Name=ANKRD13C {ECO:0000313|Ensembl:ENSOANP00000024465.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024465.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000024465.2, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024465.2,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000024465.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024465.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC       receptors, regulating their biogenesis and exit from the ER.
CC       {ECO:0000256|ARBA:ARBA00037107}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   AlphaFoldDB; F6W6M3; -.
DR   STRING; 9258.ENSOANP00000024465; -.
DR   Ensembl; ENSOANT00000024469.3; ENSOANP00000024465.2; ENSOANG00000015530.3.
DR   eggNOG; KOG0522; Eukaryota.
DR   GeneTree; ENSGT00950000182928; -.
DR   HOGENOM; CLU_026137_1_0_1; -.
DR   InParanoid; F6W6M3; -.
DR   OMA; YPMHQSV; -.
DR   OrthoDB; 20116at2759; -.
DR   TreeFam; TF314176; -.
DR   Proteomes; UP000002279; Chromosome 4.
DR   Bgee; ENSOANG00000015530; Expressed in endometrium and 7 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR   GO; GO:2000209; P:regulation of anoikis; IEA:Ensembl.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR021832; ANKRD13.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR12447; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13; 1.
DR   PANTHER; PTHR12447:SF25; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF11904; GPCR_chapero_1; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   REPEAT          149..181
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..80
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..117
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  60792 MW;  63911ED57B32A936 CRC64;
     MTGEKIRSLR RDHKPSKDEG GLLEPGDEEA AAAPGGTFTG GRTGPAGGGG GGGGGGGGGK
     AGRACHRIFS HHHHNHHHHG PTPPATQGPQ PTGAPPGPQD PAGPGAPHHG APPAPGPLHF
     PLHECVFKGD VRRLSSFIRT HNIGQKDNHG NTPLHLAVML GSKECAHLLL AHNAPVKVKN
     AQGWSPLAEA ISYGDRQMIT ALLRKLKQQS RESVEEKRPR LLKALKELGD FYLELHWDFQ
     SWVPLLSRIL PSDACKIYKQ GINIRLDTTL IDFTDMKCQR GDLSFIFNGD AAPSESFVVL
     DNEQKVYQRI HHEESEMETE EEVDILMSSD IYSATLSTKS ITFTRAQTGW LFREDKTERV
     GNFLADFYLV NGLVLESRKR REHLSEEDIL RNKAIMESLS KGGNLMEQNF EPVRRQSLTP
     PPPNTITWEE YISAENGKAP HLGRELVCKE SKKTFKATIA MSQEFPLGIE SLLNVLEVIA
     PFKHFNKLRE FVQMKLPPGF PVKLDIPVFP TITATVTFQE FRYDEFDESI FTIPDDYKED
     PSRFPDL
//
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