ID F6WAK4_XENTR Unreviewed; 1198 AA.
AC F6WAK4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Sortilin-related VPS10 domain-containing receptor 3 {ECO:0000313|Ensembl:ENSXETP00000007825};
DE SubName: Full=VPS10 domain-containing receptor SorCS3 {ECO:0000313|RefSeq:XP_031761560.1};
GN Name=sorcs3 {ECO:0000313|Ensembl:ENSXETP00000007825,
GN ECO:0000313|RefSeq:XP_031761560.1,
GN ECO:0000313|Xenbase:XB-GENE-996343};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000007825};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000007825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007825};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000007825}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031761560.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031761560.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031761560.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR RefSeq; XP_031761560.1; XM_031905700.1.
DR Ensembl; ENSXETT00000007825; ENSXETP00000007825; ENSXETG00000003625.
DR KEGG; xtr:100498333; -.
DR AGR; Xenbase:XB-GENE-996343; -.
DR Xenbase; XB-GENE-996343; sorcs3.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_010702_0_0_1; -.
DR OMA; RRNDGNC; -.
DR TreeFam; TF324918; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000003625; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_031761560.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1198
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157420"
FT TRANSMEM 1102..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 836..876
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 62..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 134250 MW; 6ABB81770BC058B0 CRC64;
MGSRGAPRML GFLWLCLLLG TPSRGEITCR HCHPHIQPGR EVVRDPMGGK AGNVRGALGS
LEPQLLGGQQ PTSTVSGSHS WRSAPLPPGG DPQAPYTGQG GGRMKRHSQS GAGGPHKEIL
LPSGPTDEDL VSRMVKRSES KGSREEGRLP RARGQELTLS STSFPLTGDS AHNQAMVHWT
GGGNSSVILI LTKLYDFNLG SVTESSLWRS TDYGTTYEKF NEKVGLKTVL SYLYVSPTNK
RKIMLLSDPD MESSILISSD AGATYQKYRL NFYIQSLLFH PKQEDWVLAY SLDQKLYSSM
DFGRRWNLMH ERITPNRFYW SVTGLDKEPD LVHMEARSAD GQAHYITCRI QECSETTRGG
PFPRSIDTNS LVVQDEYVFI QVTSGGRANY YVSYKREAFA QIKLPKYSLP KDMHIISTDQ
KQVFAAVQEW NQNETYNLYI SDTRGVFFTL ALENVKSSRG VEGNIVIDLY EVAGVKGLFL
ANKKVDEQIK TFITYNKGRD WRLLQAPDTD LRGNPITCLL PFCSLHFHLQ MSENPYNSGS
ISSKVTVPWL IVASGNVGSE LSPTDTNMFI SSDGGNTWKH IFEEEYNIWY LDWGGALVAM
KHTTLPVRHL WLSFDEGRSW NKYAFTSVPL FVDGALIEPG LENHIMTVFG HFSLRSEWQL
VKVDYKSIFG RRCNENDFES WHLNNQRDFC VMGERKTYRK RRPGSQCLLG KDYLRTITEP
CLCSHWDFEC DYGYERHGKN QCSPAFWFNP TSVSGDCGQG QSYLRSSGYR RIVSNNCTDG
LRDQYSAKPQ QCLGKAPQGL HLVTTDGKLG AQQGQNVTFL VHLEEGDLQR INIQLDFGDG
SAVSYSNFSK IEDGIRHVYK NTGIYQVTAY AENSIGIDSS ILYLHVTSPL EYVHLRVPFV
AIRNKEANAS AVVWPSHSGT LTHFWWIGNS TKPLITLENS ISFMFNSEGI NTITVQVSSG
GTLIQDTKEI AVHEYFQSQL LSFSPNLDYH NPDIPEWRQD ISRLITRALI QVTNIPEEHI
LVAMFPGLPT SAEVFVLPPK NASERRKGSK GDLEQMVETL LSALNQNLVV FELKPGVQVF
VYVTQLTLAP LVDSGSGHSS SAMLMLLSVV FLGLAVFLIY KFKRKIPWIN IYAQVQHDKE
QEMIGSVSQN DTAPKISLGN FPDSEELSDK ELDTRVIGTI STIANSESTK EIPNCTSV
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