ID F6WC15_MOUSE Unreviewed; 109 AA.
AC F6WC15;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Guanine nucleotide-binding protein G(o) subunit alpha {ECO:0000256|ARBA:ARBA00040796};
DE Flags: Fragment;
GN Name=Gnao1 {ECO:0000313|Ensembl:ENSMUSP00000118463.2,
GN ECO:0000313|MGI:MGI:95775};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118463.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000118463.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118463.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000118463.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118463.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC {ECO:0000256|ARBA:ARBA00006628}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6WC15; -.
DR SMR; F6WC15; -.
DR SwissPalm; F6WC15; -.
DR jPOST; F6WC15; -.
DR MaxQB; F6WC15; -.
DR PeptideAtlas; F6WC15; -.
DR ProteomicsDB; 372088; -.
DR Antibodypedia; 3649; 299 antibodies from 34 providers.
DR Ensembl; ENSMUST00000142466.2; ENSMUSP00000118463.2; ENSMUSG00000031748.17.
DR AGR; MGI:95775; -.
DR MGI; MGI:95775; Gnao1.
DR VEuPathDB; HostDB:ENSMUSG00000031748; -.
DR GeneTree; ENSGT00940000155883; -.
DR HOGENOM; CLU_014184_7_5_1; -.
DR ChiTaRS; Gnao1; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000031748; Expressed in perirhinal cortex and 234 other cell types or tissues.
DR ExpressionAtlas; F6WC15; baseline and differential.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF355; GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Proteomics identification {ECO:0007829|MaxQB:F6WC15,
KW ECO:0007829|PeptideAtlas:F6WC15};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000118463.2"
SQ SEQUENCE 109 AA; 12601 MW; FD8F21BAC82B178F CRC64;
QVLHEDETTN RMHESLMLFD SICNNKFFID TSIILFLNKK DLFGEKIKKS PLTICFPEYP
GSNTYEDAAA YIQTQFESKN RSPNKEIYCH MTCATDTNNI QTASWTLCC
//
