ID F6WDW8_MACMU Unreviewed; 1502 AA.
AC F6WDW8; H9FPC6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Nischarin {ECO:0000313|EMBL:AFE76485.1, ECO:0000313|Ensembl:ENSMMUP00000007426.4};
GN Name=NISCH {ECO:0000313|EMBL:AFE76485.1,
GN ECO:0000313|Ensembl:ENSMMUP00000007426.4,
GN ECO:0000313|VGNC:VGNC:84147};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007426.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AFE76485.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE76485.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000007426.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007426.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JU332730; AFE76485.1; -; mRNA.
DR RefSeq; XP_014986241.1; XM_015130755.1.
DR Ensembl; ENSMMUT00000007901.4; ENSMMUP00000007426.4; ENSMMUG00000005619.4.
DR GeneID; 696916; -.
DR KEGG; mcc:696916; -.
DR CTD; 11188; -.
DR VEuPathDB; HostDB:ENSMMUG00000005619; -.
DR VGNC; VGNC:84147; NISCH.
DR GeneTree; ENSGT00940000156494; -.
DR HOGENOM; CLU_252294_0_0_1; -.
DR OrthoDB; 2918075at2759; -.
DR TreeFam; TF320547; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000005619; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06875; PX_IRAS; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR037904; Nischarin_PX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..121
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 463..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..648
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..685
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1502 AA; 166568 MW; BD2CA14B524343EF CRC64;
MATLRTFGPE REAEPAKEAR VVGSELVDTY TVYIIQVTDG SHEWTVKHRY SDFHDLHEKL
VAERKIDKNL LPPKKIIGKN SRSLVEKREK DLEVYLQKLL AAFPGVTPRV LAHFLHFHFY
EINGITAALA EELFEKGEQL LGAGEVFAIG PLQLYAVTEQ LQQGKPTCAS GDAKTDLGHI
LDFTCRLKYL KVSGTEGPFG TSNIQEQLLP FDLSIFKSLH QVEISHCDAK HIRGLVASKP
TLATLSVRFS ATSMKEVLVP EASEFDEWEP EGTALEGPVT AVIPTWQALT TLDLSHNSIS
EIDESVKLIP KIEFLDLSHN GLLVVDNLQH LYNLVHLDLS YNKLSSLEGL HTKLGNIKTL
NLAGNLLESL SGLHKLYSLV NLDLRDNRIE QMEEVRSIGS LPCLEHVSLL NNPLSIIPDY
RTKVLAQFGE RASEVCLDDT VTTEKELDTV EVLKAIQKAK EVKSKLSNPE KRGGEDSRLS
AAPCIRPSSS PPTVAPASAS LPQPILSNQG IVFVQEEALA SSLSSTDSLT PEDQPIAQGC
SNSLESIPAG QAASDDLRDM PGAVGGASPD HAEPEVQVVP GSGQIIFLPF TCIGYTATNQ
DFIQRLSTLI RQAIERQLPA WIEAANQREE GQGEEEEEEE EEEEDVAENR YFEMGPPDVE
EEEEGGQGEE EEEEEEEDEE AEEERLALEW ALGADEDFLL EHIRILKVLW CFLIHVQGSI
RQFAACLVLT DFGIAVFEIP HQESRGSSQH ILSSLRFVFC FPHGDLTEFG FLMPELCLVL
KVRHSENTLF IISDAANLHE FHADLRSCFA PQHMAMLCSP ILYGSHTSLQ EFLRQLLTFY
KVAGGCQERS QGCFPVYLVY SDKRMVQTAA GDYSGNIEWA SCTLCSAVRR SCCAPSEAVK
SAAIPYWLLL TPQHLNVIKA DFNPMPNRGT HNCRNRNSFK LSRVPLSTVL LDPTRSCTQP
RGAFADGHVL ELLVGYRFVT AIFVLPHEKF HFLRIYSQLR ASLQDLKTVV IAKTPGTGGS
PQGPFADGQP AERRVSNDQR PQEVPAEALA PAPAEVPAPA PAAASASGPG KTPAPAETST
STLVPEETPV EAPAPPPAEA PAQYPSEHLI QATSEENQIP SHLPACPSLR HVASLRGSAI
IELFHSSIAE VENEELRHLM WSSVVFYQTP GLEVTACVLL STKAVYFVLH DGLRRYFSEP
LQDFWHQKNT DYNNSPFHIS QCFVLKLSDL QSVNVGLFDQ HFRLTGSTPV QVVTCLTRDS
YLTHCFLQHL MVVLSSLERT PSPEPVDKDF YSEFGNKTTG KMENYELIHS SRVKFTYPSE
EEIGDLTFIV AQKMAEPEKA PALSILLYVQ AFQVGMPPPG CCRGPLRPKT LVLTSSEIFL
LDEDCIHYPL PEFAKEPPQR DRYRLDDGRR VRDLDRVLMG YQTYPQALTL VFDDVQGHDL
MGSVTLDHFG EVPGGPARAG QGREVQWQVF VPSAESREKL ISLLARQWEA LCGRELPVEL
TG
//
