ID F6WML4_HORSE Unreviewed; 771 AA.
AC F6WML4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=ADAM metallopeptidase domain 11 {ECO:0000313|Ensembl:ENSECAP00000021415.2};
GN Name=ADAM11 {ECO:0000313|Ensembl:ENSECAP00000021415.2,
GN ECO:0000313|VGNC:VGNC:15046};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021415.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021415.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021415.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021415.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021415.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; F6WML4; -.
DR SMR; F6WML4; -.
DR STRING; 9796.ENSECAP00000021415; -.
DR PaxDb; 9796-ENSECAP00000021415; -.
DR Ensembl; ENSECAT00000025727.3; ENSECAP00000021415.2; ENSECAG00000023662.3.
DR VGNC; VGNC:15046; ADAM11.
DR GeneTree; ENSGT00940000159790; -.
DR HOGENOM; CLU_012714_5_2_1; -.
DR InParanoid; F6WML4; -.
DR OMA; WGYSAAD; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000023662; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF114; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 11; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..771
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018600509"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..440
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 446..533
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 675..712
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 46..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 505..525
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 702..711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 771 AA; 84058 MW; A07DD27C3A772811 CRC64;
MRRLRRWAFA ALLLLLPLLP PPGLGIRGPA GALRWRVSPQ LGVSEAPEVT EPSRLVGESS
GGEVRKQQLD TRVRQEPPGG PPAHLAQVSF VIPAFNSDFT LDLELNHHLL SSQYVERHFS
REGTTQHSTG AGDHCYYQGQ LRGNPRSFAA LSTCQGLHGV FSDGNFTYVV EPREMARPQE
APQGPLPHLI YRTPLLPAPL GCREPGCLFT APAHSAPPNR PRLRRKRQVR RGHPTVHSET
KYVELIVIND HQLFEQMRQS VVLTSNFAKS VVNLADVMYK EQLNTRIVLV AMETWADGDK
IQVQDDLLET LARLMVYRRE GLPEPSDATH LFSGRTFQST SSGAAYVGGI CSLSRGGGVN
EYDNMGAMAV TLAQTLGQNL GMMWNKHRSS AGDCKCPDNW LGCIMEDTGF YLPRKFSRCS
IDEYNQFLQE GGGSCLFNKP LKLLDPPECG NGFVEAGEEC DCGSVQECSR AGGNCCKKCT
LTHDAMCSDG LCCRRCKYEP RGVSCREAVN ECDIAETCTG DSSQCPPNLH KLDGYYCDHE
QGRCYGGRCK TRDQQCQALW GHAAADRFCY EKLNVEGTER GNCGRKGSGW VQCNKQDVLC
GFLLCVNISG APRLGDLGGD ISSVTFYHQG KELDCRGGHV QLADGSDLSY VEDGTACGPN
MLCLDHRCLP ASAFNFSTCP GSGERRICSH HGVCSNEGKC ICQPDWTGKD CSIHNPLPTS
PPTGETERYK GPSGTNIIIG SIAGAVLVAA IVLGGTGWGF KNIRRGRSGG A
//