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Database: UniProt
Entry: F6WN29_XENTR
LinkDB: F6WN29_XENTR
Original site: F6WN29_XENTR 
ID   F6WN29_XENTR            Unreviewed;      1177 AA.
AC   F6WN29;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 40.
DE   SubName: Full=Sodium channel, voltage-gated, type V alpha subunit {ECO:0000313|Ensembl:ENSXETP00000031187};
GN   Name=scn5a {ECO:0000313|Ensembl:ENSXETP00000031187};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000031187, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000031187}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000031187};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000031187}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXETP00000031187}.
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DR   EMBL; AAMC01012929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01012938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSXETT00000031187; ENSXETP00000031187; ENSXETG00000004251.
DR   Xenbase; XB-GENE-6037407; scn5a.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000004251; -.
DR   ExpressionAtlas; F6WN29; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     55     82       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    387    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    440       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    497    525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    585    610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    840    858       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    879    895       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    907    927       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    982       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1084   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        7     88       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      145    336       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      387    614       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      624    834       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      838   1116       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       79    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1177 AA;  133849 MW;  75F58F02DE7770C2 CRC64;
     CPDGFICMKT GRNPNYGYTS FDTFGWAFLS LFRLMTQDYW ENLYQQTLRA AGKTYMIFFV
     FVIFLGSFYL VNLILAVVAM AYEEQNQATI AEAEAKEREF QQAMEQLKKE QEALASKGPD
     AASHSSCEMS PFSSKSAKER RNRRKKKKSS ETEEYGEDMK PPRGEMDEES LRKMVILHSE
     TSTSKRRISQ GSIFNFRFRN RDLCSETEFA DDEVSNASDG HRGSLLVPRA GRRQSTQSQT
     SPLSFANTPG YTQNGKRNSS VDCNGVVSLV GGAGTYSNPT SPGGLLLPAV IVEKSGAEAS
     PTDLELSRMQ LLMPHALSVE YVDQPFQRQR AVSTVSVLTN ALEELEESRQ KCPPCWNHFA
     QSYLIWDCCS LWLDIKDGVK FVVMDPFIDL TITICIVLNT LFMALEHYKM TPEFEYMLSV
     GNYVFTGIFT AEMVFKIIAL DPYYYFQQGW NIFDSIIVCL SLMELCLASM GNLSVLRSFR
     LLRVFKLAKS WPTLNTLIKI IGNSVGALGN LTLVLAIIVF IFAVVGVQLF GRNYFECVCK
     ISAECKLPRW HMHDFFHSFL IVFRVLCGEW IETMWDCMEV AGQPLCILVF MLVMVIGNLV
     VLNLFLALLL SSFSADNLSA PDEDGEMNNL QIAIARIQRG IRFVKKAIVD FFCNLFTRPD
     KPAQAFKSNL STKNQNINNI NLNNHINMSN TCKEDFREGN STNGGISKNG EKYVVSESDD
     YMTSPRLSVC VPIALGESDV EYHEEDEQSI FTDVEISKEN AQDKKQDDSI SECSTVDLRK
     SRELIEQLPE SSEEFADPEE CFTEGCLRYC SCCRIDITTG AGKIWWKLRK TCFKIVEHNW
     FETFIIFMIL LSSGALAFED IYIDQKKVVK TILEYADKVF TYVFVLEMLL KWVAYGFKKY
     FTNAWCWLDF FIVDVSLISL LATPLGLSEL GPMKSLRTLR ALRPLRALSR FEGMRVVVNA
     LIGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFGKCVNA TTKEELSYLT VDNKSMCNDF
     INTEAYWTKT KVNFDNVGAG YLALLQVVGR GRYDGPLWFS MSLSAIRKGT IEQQPIYEIN
     KYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS
     KKPQKPIPRP LNKFQGFVFD IVTKQAFDII IMILICL
//
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