ID F6WNC3_HORSE Unreviewed; 1279 AA.
AC F6WNC3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=BMS1 ribosome biosis factor {ECO:0000313|Ensembl:ENSECAP00000002870.3};
GN Name=BMS1 {ECO:0000313|Ensembl:ENSECAP00000002870.3,
GN ECO:0000313|VGNC:VGNC:15854};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002870.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002870.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002870.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002870.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002870.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR STRING; 9796.ENSECAP00000002870; -.
DR PaxDb; 9796-ENSECAP00000002870; -.
DR Ensembl; ENSECAT00000004160.3; ENSECAP00000002870.3; ENSECAG00000001358.3.
DR VGNC; VGNC:15854; BMS1.
DR GeneTree; ENSGT00940000153195; -.
DR HOGENOM; CLU_002486_0_1_1; -.
DR InParanoid; F6WNC3; -.
DR OMA; KLHVPMV; -.
DR OrthoDB; 5478101at2759; -.
DR TreeFam; TF105751; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000001358; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; F6WNC3; baseline.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd01882; BMS1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR037875; Bms1_N.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR PANTHER; PTHR12858:SF2; RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 80..245
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..536
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..603
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1279 AA; 145973 MW; B5F7C3AE5FCDDC6C CRC64;
METKDQKKHR KKNSGPKAEK KRKRHLQDLQ LGDEEDARKR NPKAFAVQSA VRMARSFHRT
QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ CLIRNFTRQK LTEIRGPVTI
VSGKKRRLTI IECGCDINVM IDLAKVADLV LMLIDASFGF EMETFEFLNI CQVHGFPKIM
GVLTHLDSFK YNKQLKKTKK RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT
VMKFRPLTWQ TSHPYILVDR MEDLTNPEDI RTNIKCDRKV SLYGYLRGAH LKNRSQIHMP
GDFAVSDVSF LPDPCALPEQ QKKRCLNEKE KLVYAPLSGV GGVLYDKDAV YVDLGGSHGF
QESDEARPTH ELVQSLISTH STIDAKMASS RVTLFSDSKP LGSEDIDNQG LWMPKEEKQM
DLKTGRVRRK AIFGDEEDES GDSDDENDEE MSEGDSLENS SSDDETEKEE DAEMADKEYM
TGKGVKRQRL EEMEEDVEVD LPAFADSDDD LERSSEEEEA EEADESSEEE DSASEGERDI
LESKAVGEGS KAGLSDSLNP EKSLTMKKAI LTTSDSGHCT AEEAFASEDE SEESSSLSTE
GEDSENEEVT RKKIPESSQV VSGQKLGLEN LINETSDVED LLREEESYKE ENKFPTETSG
ALKWKEDLSR KAAEAFLRQQ QATPNLRKLI YGTVTEDNEE DDDDTREEIG GLFRVSQPAR
ECKHKADSLD CSRFHVEAPH DWDLEEVMNS IRDCFVTGKW EEDKDAAKIL AEDEELYGDF
EDLETGDVHK GKSGPDTQIE DVEEEVKEEI DRSTEESAKK KHLDKKRKLK EMFDAEYDEG
ESTYFDDLKG EMQKQAQLNR AEFEDQDDEA RVQYEGFRPG MYVRIEIENV PCEFVLNFDP
HYPIILGGLG NSEGNVGYVQ MRLKKHRWYK KILKSRDPII FSVGWRRFQT IPLYYIEDHN
GRQRLLKYTP QHMHCGATFW GPITPQGTGF LAVQSVSGVM PDFRIAATGV VLDLDKSIKI
VKKLKLTGFP FKIFKNTSFI KGMFNSALEV AKFEGAVIRT VSGIRGQIKK ALRAPEGAFR
ASFEDKLLMS DIVFMRTWYP VSIPAFYNPV TSLLKPVGEK DTWSGMRTTG QLRLAHGVKL
KPNKDSLYKP IMRQKKHFNS LHIPKALQKA LPFKNKPKTQ AKAGKVPKDR LRPAVVREPH
ERKILALLDA LSTVHSQKMK KAKVQQHLHN KEHFKAKQKE EEEKLKRQKD LRKKLFRIQG
QKERRNQKSS LKGPEEQSK
//
