ID F6WNR2_CIOIN Unreviewed; 680 AA.
AC F6WNR2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN Name=LOC100179058 {ECO:0000313|Ensembl:ENSCINP00000018703.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000018703.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000018703.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000256|ARBA:ARBA00003823,
CC ECO:0000256|RuleBase:RU365057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU365057}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC ECO:0000256|RuleBase:RU365057}.
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DR AlphaFoldDB; F6WNR2; -.
DR STRING; 7719.ENSCINP00000018703; -.
DR Ensembl; ENSCINT00000018703.3; ENSCINP00000018703.3; ENSCING00000009198.3.
DR GeneTree; ENSGT00390000010355; -.
DR HOGENOM; CLU_009161_3_1_1; -.
DR InParanoid; F6WNR2; -.
DR OMA; AMYKTYK; -.
DR TreeFam; TF105727; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR048292; SDA1_C.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF21638; SDA1_C; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365057};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU365057};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT DOMAIN 62..422
FT /note="SDA1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08158"
FT DOMAIN 496..614
FT /note="SDA1 middle"
FT /evidence="ECO:0000259|Pfam:PF05285"
FT DOMAIN 633..677
FT /note="SDA1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21638"
FT REGION 480..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 78561 MW; 715F225ADCE7EB72 CRC64;
SAMGRTSQLP DNLPQLQNLI KRDPESYRAE FEQQYRRYES NLQVFLLQPS EDAKSLSELT
MFIGQVAHCY PDVVGEFPEQ LREILKRHAS ALHPEIRMMF CRALMLLRNK KLISPASLFE
LFFELFRCSD KLLRKTLYNF IIQDIKNLNI GHKDNKLNKT LQNFMYTMLS DSNSMAAKMS
LNAMAELYNR KVWNDAKTVN VISTACFSKF TKVLSASLRF FLGQDKQVAD SDSEAEEEGP
SARDIILRFA TKKKSTRAKA KRDKALKVLN KHKRKMKKQN TDFSAIHLLH DPQGFVERLF
KQLQKTNESF EIRLLYIVVI SRIVGVHQLF LFNFYPFIQR FLQPHQRDVT KLLLAVAQAS
HELVPPEIIR TIIMTIANNF VSERNSSEVM GVGLNAVREI CARCPLAMTE DLLRDLTQYK
TRHDKAVTSA ARSLIQLYRR INPTMLFKKF QGKPTEASTE LQTTEYGKLV VKDYIPGAEA
LPETPEVDED NTVQDGWESC SNASDNDGSW KNVSSDEEEP AAEDETAGMD PEEKIQKAQI
VSQMRLLTQE EFQRVRAQQA SKEVLPAARK RKVVSLDSKE ERYNAELVAL NDIELVHKKR
PHDRESRLAT VLRGREDREK FGRKKAKMDP FASTTNKEKR KKKPFMMVRE KMKKKKSGRS
FREKQMALRA ALVKRAKRYK
//
