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Database: UniProt
Entry: F6WSR8_HORSE
LinkDB: F6WSR8_HORSE
Original site: F6WSR8_HORSE 
ID   F6WSR8_HORSE            Unreviewed;      4345 AA.
AC   F6WSR8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSECAP00000007386};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSECAP00000007386};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007386, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000007386, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007386,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000007386}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007386};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000007386}.
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DR   PaxDb; F6WSR8; -.
DR   Ensembl; ENSECAT00000009665; ENSECAP00000007386; ENSECAG00000006795.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000006795; -.
DR   ExpressionAtlas; F6WSR8; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4135   4161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4182   4204       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11     66       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       73    118       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      126    181       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      187    244       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      252    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      500    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1123       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1463       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3925   3960       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4314   4338       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4345 AA;  492381 MW;  C751E5BAA6F40D72 CRC64;
     FSMQTAQGGS HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW
     WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS
     GSEAAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET
     LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD
     VGVRKEVDGM GTSEIKYGDS VCYIQHVNTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM
     DDGLNLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL
     IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG
     REAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL
     VESPEALNII KEGHIKSIIS LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG
     RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS
     TEGYSPYPGG GEEWGGNGVG DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL
     DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY
     APCYEAVLPK EKLKVEHSRE YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE
     RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET
     LKTLLALGCH VGISDEHAEE KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL
     AENAHNVWAR DRVRQGWTYG IQQDVKNRRN PRLVPYALLD DRTKKSNKDS LREAVRTLLG
     YGYNLEAPDQ DHAARAEVCS GTGERFRIFR AEKTYAVKAG RWYFEFEAVT AGDMRVGWSR
     PGCQPDQELG SDECAFAFDG FKAQRWHQGN EHYGRSWQAG DVVGCMVDMT EHTMMFTLNG
     EILLDDSGSE LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF
     AVNTNRDITM WLSKRLPQFL QVPSNHEHIE VTRIDGTIDS CPCLKVTQKS FGSQNSSTDI
     MFYRLSMPIE CAEVFSKTAG SGIPGAGLFG PKNDLEDYDA DSDFEVLMKT AHGHLVPDRV
     DKDKEATKPE FNNHKDYAQE KPSRLKQRFL LRRTKPDYST SHSARLTEDV LADDRDDYDY
     LMQTSTYYYS VRIFPGQEPA NVWVGWITSD FHQYDTGFDL DRVRTVTVTL GDEKGKVHES
     IKRSNCYMVC AGESMSPGQG RNNNGLEIGC VVDAASGLLT FTANGKELST YYQVEPSTKL
     FPAVFAQATS PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM
     PNQFLKVDVS RISERQGWLV QCMDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR
     LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL
     MMNSEFIVPM TEETKSITLF PDENKKHGLP GIGLSTSLRP RMFSSPSFVS INNDCYQYSP
     EFPLDILKAK TIQMLTEAVK QGSLHARDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK
     HILQLIEPSV FKEAASPEEE SEALEKEPCA EDSKLEGAGD EEAKEGERPK EGLLQMKLPE
     PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA LNMSAALTAR
     KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH EDLMTHCGIE LDEDGSLDGN
     SDLTIRGRLL SLVEKVTYLK KKQAEKPVES DSKKSSTLQQ LISETMVRWA QESVIEDPEL
     VRAMFVLLHR QYDGIGGLVR ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK
     LMIRGLGDIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL
     CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN NELALALREP
     DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPVEGERYLD FLRFAVFCNG ESVEENANVV
     VRLLIRRPEC FGPALRGEGG NGLLAVMEEA IKIAEDPSRD GPSPTSGSSR TPDTEEEEDD
     TIHMGNAIMT FYAALIDLLG RCAPEMHLIH AGKGEAIRIR SILRSLIPLG DLVGVISIGF
     QMPTIAKDGN VVEPDMSAGF CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA
     SLDTAALSAT DMALALNRYL CTAVLPLLTR CAPLFAGTEH HASLIDSLLH TVYRLSKGCS
     LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN EHAKMPLKLL TNHYERCWKY
     YCLPGGWGNF GAASEEELHL SRKLFWGIFD ALSQKKYEQE LFKLALPCLS AVAGALPPDY
     MESNYVSMME KQSSMDSEGN FNPQPVDTSN ITIPEKLEYF INKYAEHSHD KWSMDKLANG
     WIYGEIYSDS SKVQPLMKPY KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL
     YNRTRRISQT SQVSVDAAHG YSPRAIDMSN VTLSRDLHAM AEMMAENYHN IWAKKKKLEL
     ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING YVVSRGFKDL ELDTPSIEKR
     FAYSFLQQLI RYVDEAHQYI LEFDGGSRSK GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL
     YFLSAASRPL CSGGHASNKE KEMVTSLFCK LGVLVRHRIS LFGNDATSIV NCLHILGQTL
     DARTVMKTGL ESVKSALRAF LDNAAEDLEK TMENLKQGQF THTRNQPKGV TQIINYTTVA
     LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER QRSALGECLA
     AFAGAFPVAF LETHLDKHNI YSIYNTKSSR ERAALNLPTN VEDVCPNIPS LEKLMEEIVE
     LAESGIRYTQ MPHVMEVILP MLCSYMSRWW EHGPENNPER TEMCCTALNS EHMNTLLGNI
     LKIIYNNLGI DEGAWMKRLA VFSQPIINKV KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL
     KAEARGDMSE AELLILDEFT TLARDLYAFY PLLIRFVDYN RAKWLKEPNP EAEDLFRMVA
     EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS KAAVSDQERK KMKRKGDRYS
     MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSMKD TEDEVRDIIR NNIHLQGKLE
     DPAIRWQMAL YKDLPNRTED TSDPEKTVER VLDIANVLFH LEQTSPRIVL KRYNCLIVEH
     PQRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRAVN LFLQGYEKSW IETEEHYFED
     KLIEDLAKPG AEPPEEDEGT KRVDPLHQLI LLFSRTALTE KCKLEEDFLY MAYADIMAKS
     CHDEEDDDGE EEVKSFEEKE MEKQKLLYQQ ARLHDRGAAE MVLQTISASK GETGPMVAAT
     LKLGIAILNG GNSTVQQKML DYLKEKKDVG FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG
     MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE GHNSDFQNYL RTQTGNNTTV NIIISTVDYL
     LRVQESISDF YWYYSGKDVI DEQGQRNFSK AIQVAKQVFN TLTEYIQGPC TGNQQSLAHS
     RLWDAVVGFL HVFAHMQMKL SQDSSQIELL KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ
     MVDMLVESSN NVEMILKFFD MFLKLKDLTS SDTFKEYDPD GKGVISKRDF HKAMESHKHY
     TQSETEFLLS CAETDENETL DYEEFVKRFH EPAKDIGFNV AVLLTNLSEH MPNDTRLQTF
     LELAESVLNY FQPFLGRIEI MGSAKRIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN
     EGGEKEKMEL FVNFCEDTIF EMQLAAQISE SDLNERSANK EESEKEKPEE QGPKMGFFSI
     LTVKSALFAL RYNILTLMRM LSLKSLKKQM KKVKKMTVKD MVTAFFSSYW SILMSLLHFV
     ASVFRGFSRI ICSLLLGGSL VEGAKKIKVA ELLANMPDPT QDEVRGEGEE GERKPVETAL
     ASEDLTDLKE LTEESDLLSD IFGLDLKREG GQYKLIPHNP NAGLSDLMSN PVPIPEVQDK
     FQEQKAKEEE KEEKEENKSE PEKAE
//
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