ID F6WXZ7_ORNAN Unreviewed; 322 AA.
AC F6WXZ7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Sidoreflexin {ECO:0000256|RuleBase:RU362000};
GN Name=SFXN3 {ECO:0000313|Ensembl:ENSOANP00000011653.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011653.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011653.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011653.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031,
CC ChEBI:CHEBI:33384; Evidence={ECO:0000256|ARBA:ARBA00036416};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC membrane {ECO:0000256|RuleBase:RU362000}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362000}.
CC -!- SIMILARITY: Belongs to the sideroflexin family.
CC {ECO:0000256|ARBA:ARBA00005974, ECO:0000256|RuleBase:RU362000}.
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DR AlphaFoldDB; F6WXZ7; -.
DR STRING; 9258.ENSOANP00000011653; -.
DR Ensembl; ENSOANT00000011655.2; ENSOANP00000011653.2; ENSOANG00000007319.3.
DR eggNOG; KOG3767; Eukaryota.
DR GeneTree; ENSGT01030000234641; -.
DR HOGENOM; CLU_039425_1_0_1; -.
DR InParanoid; F6WXZ7; -.
DR OMA; YDSAHHP; -.
DR TreeFam; TF313205; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000007319; Expressed in adult mammalian kidney and 8 other cell types or tissues.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015194; F:L-serine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015075; F:monoatomic ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:Ensembl.
DR GO; GO:0140300; P:serine import into mitochondrion; IBA:GO_Central.
DR InterPro; IPR004686; Mtc.
DR NCBIfam; TIGR00798; mtc; 1.
DR PANTHER; PTHR11153; SIDEROFLEXIN; 1.
DR PANTHER; PTHR11153:SF20; SIDEROFLEXIN-3; 1.
DR Pfam; PF03820; SFXNs; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU362000};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 322 AA; 35433 MW; CEAF7C83DF8147F1 CRC64;
MAGELPLGIN IRDPRWDQGT FLGRARHFFT VTDPRNLLLS GAQLEEARRT VENYRAGVVD
PGLTEDQLWR AKYIYDSAFH PDTGEKMVLI GRMSAQVPMN MMITGCMLTF YRRTPTVLFW
QWANQSFNAV VNYSNRSGDA PITVGQLGTA YVSATTGAVV TALGLKSLTQ HLPSLVGRFV
PFAAVAAANC INIPLMRQRE LQVGIPVTDE KGHRLGESVT AAQHGIVQVV VSRIGMAVPA
MAIPPVIMNA LEKREFLKRR PWLSAPLQVG LVGLCLVFAT PLCCALFPQR SSIGVSQLEP
EVQAEIRKKN PDITVVYYNK GL
//
