GenomeNet

Database: UniProt
Entry: F6WZF4_HORSE
LinkDB: F6WZF4_HORSE
Original site: F6WZF4_HORSE 
ID   F6WZF4_HORSE            Unreviewed;      4347 AA.
AC   F6WZF4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   22-NOV-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSECAP00000007367};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSECAP00000007367};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007367, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000007367, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007367,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000007367}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007367};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000007367}.
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DR   PaxDb; F6WZF4; -.
DR   Ensembl; ENSECAT00000009645; ENSECAP00000007367; ENSECAG00000006795.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000006795; -.
DR   ExpressionAtlas; F6WZF4; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4137   4163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4184   4206       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11     66       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       73    118       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      126    181       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      187    244       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      252    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      500    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1123       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1463       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3927   3962       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4316   4340       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4347 AA;  492624 MW;  44178F7BAAF86032 CRC64;
     FSMQTAQGGS HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW
     WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS
     GSEAAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET
     LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD
     VGVRKEVDGM GTSEIKYGDS VCYIQHVNTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM
     DDGLNLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL
     IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG
     REAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL
     VESPEALNII KEGHIKSIIS LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG
     RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS
     TEGYSPYPGG GEEWGGNGVG DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL
     DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY
     APCYEAVLPK EKLKVEHSRE YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE
     RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET
     LKTLLALGCH VGISDEHAEE KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL
     AENAHNVWAR DRVRQGWTYG IQQDVKNRRN PRLVPYALLD DRTKKSNKDS LREAVRTLLG
     YGYNLEAPDQ DHAARAEVCS GTGERFRIFR AEKTYAVKAG RWYFEFEAVT AGDMRVGWSR
     PGCQPDQELG SDECAFAFDG FKAQRWHQGN EHYGRSWQAG DVVGCMVDMT EHTMMFTLNG
     EILLDDSGSE LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF
     AVNTNRDITM WLSKRLPQFL QVPSNHEHIE VTRIDGTIDS CPCLKVTQKS FGSQNSSTDI
     MFYRLSMPIE CAEVFSKTAG SGIPGAGLFG PKNDLEDYDA DSDFEVLMKT AHGHLVPDRV
     DKDKEATKPE FNNHKDYAQE KPSRLKQRFL LRRTKPDYST SHSARLTEDV LADDRDDYDY
     LMQTSTYYYS VRIFPGQEPA NVWVGWITSD FHQYDTGFDL DRVRTVTVTL GDEKGKVHES
     IKRSNCYMVC AGESMSPGQG RNNNGLEIGC VVDAASGLLT FTANGKELST YYQVEPSTKL
     FPAVFAQATS PNVFQFELGR IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM
     PNQFLKVDVS RISERQGWLV QCMDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR
     LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL
     MMNSEFIVPM TEETKSITLF PDENKKHGLP GIGLSTSLRP RMFSSPSFVS INNDCYQYSP
     EFPLDILKAK TIQMLTEAVK QGSLHARDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK
     HILQLIEPSV FKEAASPEEE SEALEKEPCA EDSKLEGAGD EEAKEGERPK EGLLQMKLPE
     PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA LNMSAALTAR
     KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH EDLMTHCGIE LDEDGSLDGN
     SDLTIRGRLL SLVEKVTYLK KKQAEKPVES DSKKSSTLQQ LISETMVRWA QESVIEDPEL
     VRAMFVLLHR QYDGIGGLVR ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK
     LMIRGLGDIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL
     CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN NELALALREP
     DLEKVVVRYL AGCGLQSCQM LVSKGYPDIG WNPVEGERYL DFLRFAVFCN GESVEENANV
     VVRLLIRRPE CFGPALRGEG GNGLLAVMEE AIKIAEDPSR DGPSPTSGSS RTPDTEEEED
     DTIHMGNAIM TFYAALIDLL GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIG
     FQMPTIAKDG NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA
     ASLDTAALSA TDMALALNRY LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC
     SLTKAQRDSI EVCLLSICGQ LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK
     YYCLPGGWGN FGAASEEELH LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD
     YMESNYVSMM EKQSSMDSEG NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN
     GWIYGEIYSD SSKVQPLMKP YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA
     LYNRTRRISQ TSQVSVDAAH GYSPRAIDMS NVTLSRDLHA MAEMMAENYH NIWAKKKKLE
     LESKGGGNHP LLVPYDTLTA KEKAKDREKA QDILKFLQIN GYVVSRGFKD LELDTPSIEK
     RFAYSFLQQL IRYVDEAHQY ILEFDGGSRS KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR
     LYFLSAASRP LCSGGHASNK EKEMVTSLFC KLGVLVRHRI SLFGNDATSI VNCLHILGQT
     LDARTVMKTG LESVKSALRA FLDNAAEDLE KTMENLKQGQ FTHTRNQPKG VTQIINYTTV
     ALLPMLSSLF EHIGQHQFGE DLILEDVQVS CYRILTSLYA LGTSKSIYVE RQRSALGECL
     AAFAGAFPVA FLETHLDKHN IYSIYNTKSS RERAALNLPT NVEDVCPNIP SLEKLMEEIV
     ELAESGIRYT QMPHVMEVIL PMLCSYMSRW WEHGPENNPE RTEMCCTALN SEHMNTLLGN
     ILKIIYNNLG IDEGAWMKRL AVFSQPIINK VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH
     LKAEARGDMS EAELLILDEF TTLARDLYAF YPLLIRFVDY NRAKWLKEPN PEAEDLFRMV
     AEVFIYWSKS HNFKREEQNF VVQNEINNMS FLITDTKSKM SKAAVSDQER KKMKRKGDRY
     SMQTSLIVAA LKRLLPIGLN ICAPGDQELI ALAKNRFSMK DTEDEVRDII RNNIHLQGKL
     EDPAIRWQMA LYKDLPNRTE DTSDPEKTVE RVLDIANVLF HLEQKSTCMR RRYYNPGSTV
     EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA VNLFLQGYEK SWIETEEHYF
     EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ LILLFSRTAL TEKCKLEEDF LYMAYADIMA
     KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGETGPMVA
     ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG
     LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT TVNIIISTVD
     YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG PCTGNQQSLA
     HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK DMVVMLLSML EGNVVNGTIG
     KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK
     HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ
     TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV
     VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA NKEESEKEKP EEQGPKMGFF
     SILTVKSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV KDMVTAFFSS YWSILMSLLH
     FVASVFRGFS RIICSLLLGG SLVEGAKKIK VAELLANMPD PTQDEVRGEG EEGERKPVET
     ALASEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM SNPVPIPEVQ
     DKFQEQKAKE EEKEEKEENK SEPEKAE
//
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