ID F6X7V0_XENTR Unreviewed; 504 AA.
AC F6X7V0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Cytochrome P450 family 3 subfamily A member 4, gene 1 {ECO:0000313|Ensembl:ENSXETP00000048914};
GN Name=cyp3a4.1 {ECO:0000313|Ensembl:ENSXETP00000048914};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000048914};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000048914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000048914};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000048914}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR AlphaFoldDB; F6X7V0; -.
DR Ensembl; ENSXETT00000048914; ENSXETP00000048914; ENSXETG00000044305.
DR AGR; Xenbase:XB-GENE-971750; -.
DR eggNOG; KOG0158; Eukaryota.
DR HOGENOM; CLU_001570_5_2_1; -.
DR TreeFam; TF105087; -.
DR ExpressionAtlas; F6X7V0; differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR CDD; cd20650; CYP3A; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR008072; Cyt_P450_E_CYP3A.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24302; CYTOCHROME P450 FAMILY 3; 1.
DR PANTHER; PTHR24302:SF15; FATTY-ACID PEROXYGENASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 504 AA; 57073 MW; 7C8783880B39B4B9 CRC64;
MNLIPHLSTG ACILLAALLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL NGPLESAITV
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVSVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLNKPS DPFVIHMKKL LKTGLLSPLL ILVVIFPFLR PILEGLNLNF
VPKDFTEFFM NAVTSFREKR KKGDHSGRVD LLQLMMDSRT TGGNDLSNKH KALTDAEIMA
QSVIFIVAGY ETTSTALSYL FYNLATHPDV QQRLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGIVTLIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATH TPFTFLPFGD GPRNCIGLRF ALLSMKVAIV TLLQNFSVRP CAETLIPMEF
STIGFLQPKK PIVLKFLSRA AAHE
//
