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Database: UniProt
Entry: F6XE13_ORNAN
LinkDB: F6XE13_ORNAN
Original site: F6XE13_ORNAN 
ID   F6XE13_ORNAN            Unreviewed;       648 AA.
AC   F6XE13;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   SubName: Full=Potassium voltage-gated channel subfamily B member 1 {ECO:0000313|Ensembl:ENSOANP00000010205};
GN   Name=KCNB1 {ECO:0000313|Ensembl:ENSOANP00000010205};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000010205, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000010205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010205};
RX   PubMed=8919867; DOI=10.1007/BF02198841;
RA   Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT   "The mitochondrial genome of a monotreme--the platypus
RT   (Ornithorhynchus anatinus).";
RL   J. Mol. Evol. 42:153-159(1996).
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000010205}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000010205};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000010205}.
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DR   ProteinModelPortal; F6XE13; -.
DR   STRING; 9258.ENSOANP00000010205; -.
DR   Ensembl; ENSOANT00000010207; ENSOANP00000010205; ENSOANG00000006393.
DR   eggNOG; KOG3713; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118981; -.
DR   InParanoid; F6XE13; -.
DR   OrthoDB; EOG091G0FP3; -.
DR   TreeFam; TF313103; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000006393; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0001508; P:action potential; IEA:Ensembl.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:1900454; P:positive regulation of long term synaptic depression; IEA:Ensembl.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0098900; P:regulation of action potential; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003973; K_chnl_volt-dep_Kv2.
DR   InterPro; IPR004350; K_chnl_volt-dep_Kv2.1.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03521; Kv2channel; 2.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01514; KV21CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01495; SHABCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM      7     25       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     45     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    209    233       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        6    240       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   648 AA;  71786 MW;  E31A4E07ADCEA0F3 CRC64;
     SPLSFQILAI ISIMFIVLST IALSLNTLPE LQDIDEFGQT TDNPQLAHVE AVCIAWFTME
     YLLRFLSSPK KWKFFKGPLN AIDLLAILPY YVTIFLTESN KSVLQFQNVR RVVQIFRIMR
     ILRILKLARH STGLQSLGFT LRRSYNELGL LILFLAMGIM IFSSLVFFAE KDEDDTKFKS
     IPASFWWATI TMTTVGYGDI YPKTLLGKIV GGLCCIAGVL VIALPIPIIV NNFSEFYKEQ
     KRQEKAIKRR EALERAKRNG SIVSMNMKDA FARSIEMMDI VVDKNGETPG KKDKAQDNHL
     SPSKWKWAKR TLSETSSSKS FEMKEPGSPE KARSSSSPQH LNVQQLEDMY QKMAKTQSQP
     NLITKEPAQP GKAKEELEMD SQGVIDMRSM SSIDSFISCA TDFPDASRFS HSPLASLPEA
     GLPEGPHATP DGGRRSGFFI ESPRSSLKAG NPLKLRALKV NFLEGGRGQA LLLASGRGLS
     HQKKRRIGGP GGERTCAHSA NQTNFQALWH GTYLLYCASM ENPRLQPNRR GKSVPGYIDA
     DTDDEGQGLY GPDPGVPTAL PGAASPRYAV PNSGYPRRRD GGYRAENNHL ESSPLPTSPS
     TFLGQNCVYS MEALTGTSRG GQEKLKLENH ISPEVRVLPP PGPHDQSI
//
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