ID F6XGK2_HORSE Unreviewed; 388 AA.
AC F6XGK2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Protein NDRG3 {ECO:0000256|ARBA:ARBA00015425};
DE AltName: Full=N-myc downstream-regulated gene 3 protein {ECO:0000256|ARBA:ARBA00030207};
GN Name=NDRG3 {ECO:0000313|Ensembl:ENSECAP00000014462.1,
GN ECO:0000313|VGNC:VGNC:20616};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014462.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000014462.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014462.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000014462.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014462.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NDRG family.
CC {ECO:0000256|ARBA:ARBA00005598}.
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DR RefSeq; XP_005604672.1; XM_005604615.1.
DR AlphaFoldDB; F6XGK2; -.
DR SMR; F6XGK2; -.
DR STRING; 9796.ENSECAP00000014462; -.
DR ESTHER; horse-f6xgj6; Ndr_family.
DR MEROPS; S33.987; -.
DR PaxDb; 9796-ENSECAP00000014462; -.
DR Ensembl; ENSECAT00000017782.3; ENSECAP00000014462.1; ENSECAG00000016390.4.
DR GeneID; 100069714; -.
DR KEGG; ecb:100069714; -.
DR CTD; 57446; -.
DR VGNC; VGNC:20616; NDRG3.
DR GeneTree; ENSGT00950000182872; -.
DR InParanoid; F6XGK2; -.
DR OMA; ITQYFAV; -.
DR OrthoDB; 5352016at2759; -.
DR TreeFam; TF313168; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000016390; Expressed in cerebellum and 23 other cell types or tissues.
DR ExpressionAtlas; F6XGK2; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF20; PROTEIN NDRG3; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 332..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 388 AA; 42727 MW; 357D8B79A79CF717 CRC64;
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG LIHVTVRGLP KGNRPVILTY
HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML
PPILTHLSLK SIVGIGVGAG AYILSKFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG
LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLDIERP
LLGQNDNKSK TLKCSALLVV GDSSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
KLTEAFKYFL QGMGYIPYVQ LSHLSTEPVP SASMTRLARS RTHSTSSSIG SGESAFSRSV
TSNQSDGTQE FSESPDALDR HHTMEVSC
//
