ID F6XIH8_ORNAN Unreviewed; 1633 AA.
AC F6XIH8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Complement C5 {ECO:0000313|Ensembl:ENSOANP00000001755.2};
GN Name=C5 {ECO:0000313|Ensembl:ENSOANP00000001755.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000001755.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000001755.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001755.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000001755.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000001755.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR Ensembl; ENSOANT00000001756.3; ENSOANP00000001755.2; ENSOANG00000001103.3.
DR GeneTree; ENSGT00940000155670; -.
DR HOGENOM; CLU_001634_4_2_1; -.
DR Proteomes; UP000002279; Chromosome 4.
DR Bgee; ENSOANG00000001103; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR CDD; cd00017; ANATO; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048843; C5_CUB.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF83; COMPLEMENT C5; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21309; C5_CUB; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00023162};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00023162};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1633
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028174039"
FT DOMAIN 1486..1630
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1633 AA; 184258 MW; 0F75A24CC55991D7 CRC64;
MNILHVTCIL IFCGRSWSQE QTYVIAAPKV FRVGASEKVV IQAFGYTEGF DATISLKSYP
DKRTSYSSGN VNLSPGNQFQ DSATLTIQPK DLSEERDHVS YIYLEVVSHH FTKEKRIPIS
YENGFLFIQT DKFIYTPNQS VKVRLYSLNE ELKPALRNTT LTFVDPDGAE VEILEETDFT
GIVSFPDFKI PLNPKYGVWT IKAKYKTDFT TTATKTFEIK EYVMPHFSIS IEPENTFISY
KEFEEFKITI KASYFYNKKV AEAEVFVHFG IIEDIEQSEK KMMRKALQET LMTNGVAQVT
LNSKTALQEL EIRSLEEVDK AYLYIAVMVL ESSGGFSEEA EFVGVRYVLS PYNLNLVATS
LFLKPGMTFP IKVQVKDSQD HHVGGVLVNL KAHIIDKNQE ESPQEPMKSI TNQNDGVASF
VVNLPSDAET LEFSVKTEDP HIPEENQALK EYRAVAYSSL SQSYCYIDWP DSNKVLLVND
HISITVRPRS PYIDKITHYS YLVLSKGKIV QFGIVRKHKD SSFQSLNIPV TQDMVPSARL
LVYYIVTGEE KAELVADSVW LNVEEKCGNK LEVYLSNPES SYKPGQVLYL NMNTQFSSYA
ALSIMDKAIY GIQRKIKKPM EKLLRNLEKS DLGCGAGGGQ NNANVFHLAG LTFLTNANAD
DSAEEEKPCQ EVLRPKRCLH LKEKIDEKAS TYQKSLYKCC EQGAHKTADS CSVRASRVTS
KLGVKCGRVF KECCELATEV RANCTHKHML LGRIGFETLL AIDTPEIRSY FPESWLWEVH
HVNTRSKIPL SLPDSLTTWE VQGIGISSKG VCVPDPLQIQ VVKDIFLEMH IPYSVVRGEQ
IEMKGTVYNY RSSELRFSVQ MSAGEGICLS GSSSQDPKGI KHTRSQWKTI EGSSIQSVTF
SILPLELGLH GINFTLKSPF GSEILVKTLR VVPEGVKRET HVGFTLDPQG VYGSIASRKE
FQYKIPLDVV PKTKVKRTVS VKGTLIGEVI SAVLSPEGIS ILSNLPKGSA EAELMSIVPV
FYVFHYLESG SNWYILGSKA VSERDTLKKK MREGIISILS YRNKDYSYRM WKNEEANTWL
TAFALRILGQ INKYIPQNTN QICNSLLWLI ENCQLEDGSF KELSTYNPFK LQGTLPQEAK
EKALYLTAFS VIGIRKSFHI CPILKVNDAL NRAEEYLFNC IKNAQSTFTL AISAYALALG
DLNNPGVRSV FSQLKKEAYV KGDPPFYRFW KDTLRKKDSS MPSSATEQIV ETTSYALLAS
LLLGEMNYVK PIIKWLSEEQ RYGGGYFSTQ VPLNDDLVVS TGFSSGLATV LVKTVFHKIG
TSEEVCSFEL KIEVKDSQDD SQSFYKYSET KSKRVLACAR YKPSPREPYS ESSHAVMDIA
LPTGIGVYTE DLALLTDGID NLLTDYQIKD GHVILQLDSI PSDELLCVRF RIFELFHVGH
RSPATFAVYE YHTPDKQCTV FYDPFGNRQL DKVCEGSACK CVEAECGQMQ KEFDLTISAN
ARKATACQKD IAYVYKVEIL SLTKENSFIK YTATLLDIYK TGTSFAQKDS QITFLKKESC
TNVDIKKHKQ YLIMGKEALQ IKSGFSFKFI YPLDSLTWIE YWPSDEDCSH CQNVRATLEE
FSDDLFFSGC DDI
//
