GenomeNet

Database: UniProt
Entry: F6XN03_MONDO
LinkDB: F6XN03_MONDO
Original site: F6XN03_MONDO 
ID   F6XN03_MONDO            Unreviewed;       903 AA.
AC   F6XN03;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   25-OCT-2017, entry version 47.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSMODP00000000645};
GN   Name=TRPC6 {ECO:0000313|Ensembl:ENSMODP00000000645};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000645, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000000645, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000000645}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000000645}.
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DR   RefSeq; XP_016289367.1; XM_016433881.1.
DR   STRING; 13616.ENSMODP00000000645; -.
DR   Ensembl; ENSMODT00000000660; ENSMODP00000000645; ENSMODG00000000537.
DR   GeneID; 100011660; -.
DR   CTD; 7225; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; F6XN03; -.
DR   OMA; NRGPAYM; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000002280; Chromosome 4.
DR   Bgee; ENSMODG00000000537; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0036057; C:slit diaphragm; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0032414; P:positive regulation of ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005462; TRPC6_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF7; PTHR10117:SF7; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01647; TRPCHANNEL6.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    406    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    438    458       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    527    546       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    631    653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    702    724       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    153       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      216    248       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      216    248       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      856    891       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   903 AA;  103265 MW;  04368FE873F28CC6 CRC64;
     MNQGSPYGPR RVCTPGTGTR RNESQDYLLI DSELCEDNSL QQPTALPPYG YYPCIRGNDN
     RLAHRRQTIL REKGRRLANR GPAYMFNDHS TSLSIEEERF LDAAEYGNIP VVRKMLEECL
     SLNVNCVDYM GQNALQLAVA NEHLEITELL LKKENLSRVG DALLLAISKG YVRIVEAILN
     HPAFAEGKRL ATSPSQSELQ HDDFYAYDED GTRFSHDVTP IILAAHCQEY EIVHTLLRKG
     ARIERPHDYF CKCSECNQKQ KHDSFSHSRS RINAYRGLAS PAYLSLSSED PVMTALELSN
     ELAVLANIEK EFKNDYKRLS MQCKDFVVGL LDLCRNTEEV EAILNGDVEV NSNGGDHGRP
     SLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TIAVKFLVVL AVAVGLPFLA
     LIYWFAPCSK MGRIMRGPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAK
     QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWSQGPKEY LFELWNMLDF GMLAIFAASF
     IARFMAFWHA SKAQSIVDAN DTLKDLTSVG DNVKYYTLAR IKWDPSDPQI ISEGLYAIAV
     VLSFSRIAYI LPANESFGPL QISLGRTVKD IFKFMVIFIM VFVAFMIGMF NLYSYYYGAK
     QNEAFTTVEE SFKTLFWAIF GLSEVKSVVI NSNHKFIENT GYVLYGVYNV TMVIVLLNML
     IAMINNSFQE IEDDADVEWK FARAKLWFSY FEEGRTLPVP FNLVPSPKSL FYLLLKLKKW
     ISELFWGHKK GFEEDAEMNK LGHSKQSSIR SSEDLHLNSF SNPPRQYQKI MKRLIKRYVL
     KAQIDKESDE VNEGELKEIK QDISSLRYEL LEEKSQNTED LAELIRKLGE KLSIEPNQEG
     SNR
//
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