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Database: UniProt
Entry: F6XN48_MACMU
LinkDB: F6XN48_MACMU
Original site: F6XN48_MACMU 
ID   F6XN48_MACMU            Unreviewed;      2182 AA.
AC   F6XN48;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSMMUP00000036994};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036994, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000036994, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036994,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000036994}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036994};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000036994}.
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DR   EMBL; JSUE03005541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03005542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03005543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03005544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000043990; ENSMMUP00000036994; ENSMMUG00000004878.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000004878; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    117    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    204    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    341    362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    368    393       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    757    779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    799    815       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    835    857       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1169   1187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1207   1228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1240   1266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1304   1326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1405   1429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1485   1502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1522   1541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1621   1640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1707   1729       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      635    862       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1167   1439       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1485   1739       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1438   1465       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2182 AA;  241782 MW;  0DC84A6A236FE8C7 CRC64;
     MAESASPPSS AAAPAAEPGV TTEQPGPQSP PSSPPGLEEP LDGADPHVPH PDLAPVAFFC
     LRQTTSPRNW CIKMVCNPYP PMLVILLNCV TLGMYQPCDD MDCLSDRCKI LQVFDDFIFI
     FFAMEMVLKM VALGIFGKKC YLGDTWNRLD FFIVMAGMVE YSLDLQNINL SAIRTVRVLR
     PLKAINRVPS MRILVNLLLD TLPMLGNVLL LCFFVFFIFG IIGVQLWAGL LRNRCFLEEN
     FTIQGDVALP PYYQPEEDDE MPFICSLSGD NGIMGCHEIP PLKEQGRECC LSKDDVYDFG
     AGRQDLNASG LCVNWNRYYN VCRTGSANPH KGAINFDNIG YAWIVIFQVI TLEGWVEIMY
     YVMDAHSFYN FIYFILLIIV GSFFMINLCL VVIATQFSET KQREHRLMLE QRQRYLSSST
     VASYAEPGDC YEEIFQYVCH ILRKAKRRAL GLYQALQSRR QALGPEAPAP AKPGPHAKEP
     RHYSKPVGLG AERTRMCPRV DWTWCGQQLY TPPICFSELC PRHSPLDATP HTLVQPIPAT
     LASDPASCPC CQHEAGRRPS GLGSTDSGQE GSGSGSSAGG EDEADGDGTR SSEDRASSEL
     GKEEEEEQQA DGAVWLCGDV WRETRAKLRG IVDSKYFNRG IMMAILVNTV SMGIEHHEQP
     EELTNILEIC NVVFTSMFAL EMILKLAAFG LFDYLRNPYN IFDSIIVIIS IWEIVGQADG
     GLSVLRTFRL LRVLKLVRFM PALRRQLVVL MKTMDNVATF CMLLMLFIFI FSILGMHIFG
     CKFSLRTDTG DTVPDRKNFD SLLWAIVTVF QILTQEDWNV VLYNGMASTS PWASLYFVAL
     MTFGNYVLFN LLVAILVEGF QAEGDANRSY SDDDQSSSNM EEFDKLQEGL DSSGDPKLFP
     IPMTPNGHLD PSLPLGGHLG PAGAAGPAPR LSLQPDPMLV ALGSRKSSVM SLGRMSYDQR
     SLSSSRSSYY GPWGRSGAWA SRRSSWNSLK HKPPSAEHES LLSAERGGGA RVCEVAGDEG
     LPRPAPLHAP HAPHAHHAHH GPHLAHRHRH HRRTLSLDTR DSVDLAELVP TVGAHPRAAW
     RAAGPAPGHE DCNGRMPSIA KDVFTKMGDR RDRGEDEEEI DYTLCFRVRK MIDVYKPDWC
     EVREDWSVYL FSPENRFRVL CQTIIAHKLF DYVVLAFIFL NCITIALERP QIEAGSTERI
     FLTVSNYIFT AIFVGEMTLK VVSLGLYFGE QAYLRSSWNV LDGFLVFVSI IDIVVSLASA
     GGAKILGVLR VLRLLRTLRP LRVISRAPGL KLVVETLISS LKPIGNIVLI CCAFFIIFGI
     LGVQLFKGKF YHCLGVDTRN ITNRSDCMAA NYRWVHHKYN FDNLGQALMS LFVLASKDGW
     VNIMYNGLDA VAVDQQPVTN HNPWMLLYFI SFLLIVSFFV LNMFVGVVVE NFHKCRQHQE
     AEEARRREEK RLRRLEKKRR KAQRLPYYAT YCHTRLLIHS MCTSHYLDIF ITFIICLNVV
     TMSLEHYNQP TSLETALKYC NYMFTTVFVL EAVLKLVAFG LRRFFKDRRW NQLDLAIVLL
     SVMGITLEEI EINAALPINP TIIRIMRVLR IARVLKLLKM ATGMRALLDT VVQALPQVGN
     LGLLFMLLFF IYAALGVELF GKLVCNDENP CEGMSRHATF ENFGMAFLTL FQVSTGDNWN
     GIMKDTLRDC THDERSCLSS LQFVSPLYFV SFVLTAQFVL INVVVAVLMK HLDDSNKEAQ
     EDAEMDAELE LEMAHGLGPG PRLPAGSPGA PGRGPGGAGG GGDAEGGLCR RCYSPAQENL
     WLDSVSLIIK DSLEGELTII DNLSGSIFHH YSSPAGCKKC HHDKQEVQLA ETEAFSLNSD
     RSSSILLGDD LSLEDPTACP PGPKDSKGEL DPPEPMCVRD LDECFFPLSS TAVSPGPENF
     LCEMEEIPFN PVQSWLKHDS SQAPPSPFSP DASSPLLPMP AEFFHPAVSA SQKGPEKGTG
     TGTLPKIALQ GSWASLRSPR VNCTLLRQAT GSDTSLDASP SSSAGSLQTT LEDSLTLSDS
     PRRALGPPAP PQQRGLHQPG CTYHDSMDPR TRRAGGRGGG GEQRALETLS SLSLTSLFCP
     PPRRRSPAPR PRGSSAAPAA WPPPAPAAPA HGLARSPSWA ADRSKDPLGR APLPMGLGPL
     APPPQPLPGE LEPGDAASKR KR
//
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