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Database: UniProt
Entry: F6XRE6_MOUSE
LinkDB: F6XRE6_MOUSE
Original site: F6XRE6_MOUSE 
ID   F6XRE6_MOUSE            Unreviewed;       191 AA.
AC   F6XRE6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 38.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   Name=Tcirg1 {ECO:0000313|Ensembl:ENSMUSP00000120968,
GN   ECO:0000313|MGI:MGI:1350931};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120968, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000120968, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120968,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000120968}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120968};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000120968}.
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DR   EMBL; AC133523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MaxQB; F6XRE6; -.
DR   PaxDb; F6XRE6; -.
DR   PeptideAtlas; F6XRE6; -.
DR   PRIDE; F6XRE6; -.
DR   Ensembl; ENSMUST00000132164; ENSMUSP00000120968; ENSMUSG00000001750.
DR   MGI; MGI:1350931; Tcirg1.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Reactome; R-MMU-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   Reactome; R-MMU-77387; Insulin receptor recycling.
DR   Reactome; R-MMU-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-MMU-983712; Ion channel transport.
DR   Proteomes; UP000000589; Chromosome 19.
DR   Bgee; ENSMUSG00000001750; -.
DR   ExpressionAtlas; F6XRE6; baseline and differential.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR   GO; GO:0005765; C:lysosomal membrane; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016236; P:macroautophagy; IMP:MGI.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IMP:MGI.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|MaxQB:F6XRE6,
KW   ECO:0000213|PeptideAtlas:F6XRE6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMUSP00000120968}.
SQ   SEQUENCE   191 AA;  21759 MW;  2B422586344F5ED6 CRC64;
     XDLKVNFVAG AVEPYKAAAL ERLLWRACRG FLIASFRETE GQLEDPVTGE PATWMTFVIS
     YWGEQIGQKI RKITDCFHCH VFPYLEQEEA RFRTLQQLQQ QSQELQEVLG ETDRFLSQVL
     GRVQQLLPPW QVQIHKMKAV YLTLNQCSVN TTHKCLIAEV WCAARDLPTV QQALQSGSLP
     TPSSHSPFSS L
//
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