ID F6XWV7_HORSE Unreviewed; 2004 AA.
AC F6XWV7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PI4KA {ECO:0000313|VGNC:VGNC:50961};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021382.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021382.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021382.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021382.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021382.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR Ensembl; ENSECAT00000025688.3; ENSECAP00000021382.3; ENSECAG00000023152.4.
DR VGNC; VGNC:50961; PI4KA.
DR GeneTree; ENSGT00550000074798; -.
DR HOGENOM; CLU_000893_2_0_1; -.
DR TreeFam; TF102041; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000023152; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6XWV7; baseline.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1432..1620
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1710..1988
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2004 AA; 226357 MW; 49FA1E7D6165715B CRC64;
MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDSVVP YLLRLLKGLP KVYWVEESTA
RKGRGALPVA ESFSFCLVTL LSDVAYRDPS LRDEILEALL QVLHVLLGMC QALEIQEKEY
LCKYAIPCLI GISRAFGRYS NTEESLLSKL FPKVPPHSLR VPEELEGVRR RSFNDFRSIL
PSNLLTVCQE GTLKRKTSSV SSISQVSPER GMPPPSSPGG SAFHCFEVSY LPDGSALEPD
YYFSTISSSF SVSPLFNGIT YKEFNIPLEM LRELLNLVKK IVEEPVLKSL DAVVASVIEA
NPSADLYYST FSDPLYVAMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN MSQGELQKIL
HDADRIHNEL SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH
LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVVPSPVL VKLYKCHSQY HTVAGNDIKI
SVTNEHSEPT LNVMSGKKSQ PSMYEQLRDI AIDNICRCLK AGLTVDAVIV EAFLASLSNR
LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID
QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA
NIQDEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT
RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK
EPLRSVLQYN SAMKNDTVTP AELSELRSTI INLLDPAPEV SALINKLDFA MSTYLLSVYR
LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMADKAKTK
ENEEELERHA QFLLVNFNHI HKRIRRVADK YLSGLVDKFP HLLWSGTVLK TMLDILQTLS
LSLSADIHKD QPYYDIPDAP YRITVPDTCE ARESIVKDFA ARCGMILQEA MKWAPTVTKS
HLQATQLTER PACVKKDYSN FMASLNLRNR YAGEVYGMIR FSDATGQISD LNKMMVQELN
TALDLGNAQN YTQAMFKLTA MLISSKDCDP QLLHHLCWGP LRMFNEHGME TALACWEWLL
AGKNGVEVPF MREMSGAWQM TVEQKFGLFS AEIKEADPLA ASEASQPKPC APEVTPHYIW
IDFLVQRFEI AKYCSSDQVE IFSSLLQRSM SLNIGGAKGS MNRHVAAIGP RFKLLTLGLS
LLHADVVPNA TIRNVLREKI YSTAFDYFSC PPKFPTQGEK RLREDISIMI KFWTAMFSDK
KYLTASQLVP PDNQDTRSNL DIAVGSRQQA TQGWINTYPL SSGMSTISKK SGMSKKTNRG
SQLHKYYMKR RTLLLSLLAT EIERLITWYN PLSAPELELD QAGENSVANW RSKYISLSEK
QWKDNVNLAW SISPYLAVQL PARFKNTEAI GNEVTRLVRL DPGAVSDIPE AIKFLVTWHT
IDADAPELSH VLCWAPADPP TGLSYFSSMY PPHPLTAQYG VKVLRSFPPD AILFYIPQIV
QALRYDKMGY VREYILWAAS KSQLLAHQFI WNMKTNIYLD EEGHQKDPDI GDLLEQLVEE
ITGSLSGPAK DFYQREFDFF NKITNVSAII KPYPKGDERK KACLSALSEV KVQPGCYLPS
NPEAIVLDID YKSGTPMQSA AKAPYLAKFK VKRCGVSELE KEGLRCCSDS EDEHGAQEAD
GQKISWQAAI FKVGDDCRQD MLALQIIDLF KNIFQLVGLD LFVFPYRVVA TAPGCGVIEC
IPDCTSRDQL GRQTDFGMYD YFTRQYGDES TLAFQQARYN FIRSMAAYSL LLFLLQIKDR
HNGNIMLDKK GHIIHIDFGF MFESSPGGNL GWEPDIKLTD EMVMIMGGKM EATPFKWFME
MCVRGYLAVR PYMDAVVSLV TLMLDTGLPC FRGQTIKLLK HRFSPNMTER EAANFIMKVI
QSCFLSNRSR TYDMIQYYQN DIPY
//
