ID F6XX39_HORSE Unreviewed; 748 AA.
AC F6XX39;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Kelch like family member 5 {ECO:0000313|Ensembl:ENSECAP00000007093.4};
GN Name=KLHL5 {ECO:0000313|Ensembl:ENSECAP00000007093.4,
GN ECO:0000313|VGNC:VGNC:19479};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007093.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007093.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007093.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007093.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007093.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6XX39; -.
DR STRING; 9796.ENSECAP00000007093; -.
DR PaxDb; 9796-ENSECAP00000007093; -.
DR Ensembl; ENSECAT00000009334.4; ENSECAP00000007093.4; ENSECAG00000008627.4.
DR VGNC; VGNC:19479; KLHL5.
DR GeneTree; ENSGT00940000155358; -.
DR HOGENOM; CLU_004253_12_0_1; -.
DR InParanoid; F6XX39; -.
DR OMA; TSSCHTM; -.
DR TreeFam; TF329218; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000008627; Expressed in epithelium of bronchus and 23 other cell types or tissues.
DR CDD; cd18511; BACK_KLHL5; 1.
DR CDD; cd18337; BTB_POZ_KLHL5; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030606; KLHL5_BTB/POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF135; KELCH-LIKE PROTEIN 5; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 213..280
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 145..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 83439 MW; 778AA19F89E63A8E CRC64;
MLSVFVRANA GHILVLVGCT NLCAVLFARC LDDHLVSLRM SGSRKEFDVK QILKIRWRWF
GHQASSPNST VDSQQGEFWN RGQTGANGGR KFLDPCSLQL PLASIGYRRS SQLDFQNSPS
WPMASTSEVP AFEFTAEDCG GAHWLDRPEV DDGTSEEENE SDSSSCRTSN SSQTLSSCHT
MEPCSSDEFF QALNHAEQTF KKMENYLRHK QLCDVILVAG DRRIPAHRLV LSSVSDYFAA
MFTNDVREAR QEEIKMEGVE PNSLWSLIQY AYTGRLELKE DNIECLLSTA CLLQLSQVVE
ACCKFLMKQL HPSNCLGIRS FADAQGCTDL HKVAHNYTME HFMEVIRNQE FVLLPASEIA
KLLASDDMNI PNEETILNAL LTWVRHDLEQ RRKDLSKLLA YIRLPLLAPQ FLADMENNAL
FRDDIECQKL IMEAMKYHLL PERRPMLQSP RTKPRKSTVG TLFAVGGMDS TKGATSIEKY
DLRTNMWTPV ANMNGRRLQF GVAVLDDKLY VVGGRDGLKT LNTVECYNPK TKTWSVMPPM
STHRHGLGVA VLEGPMYAVG GHDGWSYLNT VERWDPQARQ WNFVATMSTP RSTVGVAVLS
GKLYAVGGRD GSSCLKSVEC FDPHTNKWTL CAQMSKRRGG VGVTTWNGLL YAIGGHDAPA
SNLTSRLSDC VERYDPKTDM WTAVASMSIS RDAVGVCLLG DKLYAVGGYD GQTYLNTVEA
YDPQTNEWTQ VAPLCLGRAG ACVVTVKL
//
