ID F6XYY3_XENTR Unreviewed; 301 AA.
AC F6XYY3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=sult6b1.6 {ECO:0000313|Ensembl:ENSXETP00000021305};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000021305};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000021305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000021305};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000021305}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC Evidence={ECO:0000256|ARBA:ARBA00036007};
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR AlphaFoldDB; F6XYY3; -.
DR Ensembl; ENSXETT00000021305; ENSXETP00000021305; ENSXETG00000030952.
DR eggNOG; KOG1584; Eukaryota.
DR HOGENOM; CLU_027239_1_2_1; -.
DR TreeFam; TF321745; -.
DR Bgee; ENSXETG00000030952; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF341; SULFOTRANSFERASE 6B1; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 56..288
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 301 AA; 34778 MW; 298E13FAC35FA276 CRC64;
MAYREKIAGE IQKALDAVKS TPPDKMLSRY NGVLYPALMC NQETFEALNS FETREDDILL
AAYPKCGTNW TLHLLQDMVH VVHKKDPAAV IPLLEFTGEN KFETLKEESS PRVLVTHLSY
DGIPKNFFNK QFKILVVFRN PKDTALSYFH FYNNNPVLPT YSSWDTFFED FMAGNVCWGS
YFDHVIEWNK HIDEENIMIV TFEEMKKDLE AAVKQISEFF GLSLNEEQIQ RIADKGTFKS
MKEKSEESHG AFGKIIFRKG EVGDWRNTFT EAQNQEMDAK FEACLAGTKL GEMLQYNVYC
K
//
