ID F6XZ70_CALJA Unreviewed; 377 AA.
AC F6XZ70; A0A2R8MLX2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00019474};
DE EC=5.3.99.3 {ECO:0000256|ARBA:ARBA00012203};
DE AltName: Full=Microsomal prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00031041};
GN Name=PTGES2 {ECO:0000313|EMBL:JAB08267.1,
GN ECO:0000313|Ensembl:ENSCJAP00000061803.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB08267.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000061803.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB08267.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB08267.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB44329.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB22893.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000061803.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-
CC heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644,
CC ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274;
CC Evidence={ECO:0000256|ARBA:ARBA00023930};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645;
CC Evidence={ECO:0000256|ARBA:ARBA00023930};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893,
CC ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023931};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894;
CC Evidence={ECO:0000256|ARBA:ARBA00023931};
CC -!- PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004702}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the GST superfamily.
CC {ECO:0000256|ARBA:ARBA00007409}.
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DR EMBL; GAMT01003594; JAB08267.1; -; mRNA.
DR EMBL; GAMS01000243; JAB22893.1; -; mRNA.
DR EMBL; GAMP01008426; JAB44329.1; -; mRNA.
DR RefSeq; XP_002743391.1; XM_002743345.3.
DR Ensembl; ENSCJAT00000082134.3; ENSCJAP00000061803.2; ENSCJAG00000019932.5.
DR GeneID; 100403135; -.
DR KEGG; cjc:100403135; -.
DR CTD; 80142; -.
DR eggNOG; KOG3029; Eukaryota.
DR GeneTree; ENSGT00390000000224; -.
DR HOGENOM; CLU_011226_0_0_1; -.
DR OMA; DYCLTEG; -.
DR OrthoDB; 1226at2759; -.
DR TreeFam; TF314304; -.
DR UniPathway; UPA00662; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000019932; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0016829; F:lyase activity; IEA:Ensembl.
DR GO; GO:0050220; F:prostaglandin-E synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046903; P:secretion; IEA:Ensembl.
DR CDD; cd03197; GST_C_mPGES2; 1.
DR CDD; cd03040; GST_N_mPGES2; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 6.20.200.30; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR034334; PGES2.
DR InterPro; IPR034335; PGES2_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12782; MICROSOMAL PROSTAGLANDIN E SYNTHASE-2; 1.
DR PANTHER; PTHR12782:SF5; PROSTAGLANDIN E SYNTHASE 2; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01203; Prostaglandin_E_synthase_like1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Prostaglandin biosynthesis {ECO:0000256|ARBA:ARBA00022585};
KW Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 104..172
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13417"
SQ SEQUENCE 377 AA; 41920 MW; 84C9B16EC6F9A76A CRC64;
MAPAARVARA LWPGGCALAW RLSGRPQLLL PTQNRAGFAG SAGGPGPVAA ALKGSPRLLG
AAALALGGAL GLYHTARWHL RAQDLHAEHS AAQLSLSSHL QLTLYQYKTC PFCSKVRAFL
DFHALPYQVV EVNPVRRAEI KFSSYRKVPI LVAQVGENSQ QLNDSSVIIS ALKTYLVSGQ
PLEEIITYYP AMKAVNDQGK EVTEFGNKYW LMLDEKEAQQ VYSGKEARTE EMKWRQWADD
WLVHLISPNV YRTPTEALAS FDYIVREGKF GAVEGAVAKY MGAAAMYLIS KRLKSRHHLQ
DNVREDLYEA ANKWVTAVGK DRPFMGGQRP NLADLAVYGV LRVMEGLDAF DDLMQHTRIQ
PWYLRVERAI TEASPAH
//
