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Database: UniProt
Entry: F6Y4B6_HORSE
LinkDB: F6Y4B6_HORSE
Original site: F6Y4B6_HORSE 
ID   F6Y4B6_HORSE            Unreviewed;      1965 AA.
AC   F6Y4B6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSECAP00000002640};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002640, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000002640, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002640,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000002640}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002640};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000002640}.
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DR   PaxDb; F6Y4B6; -.
DR   Ensembl; ENSECAT00000003788; ENSECAP00000002640; ENSECAG00000000813.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000002281; Chromosome 16.
DR   Bgee; ENSECAG00000000813; -.
DR   ExpressionAtlas; F6Y4B6; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    881    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1153   1172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1193   1209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1221   1242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1392   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1477   1495       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1507   1525       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1537   1557       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1594   1622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1697   1720       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    945       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1148       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1152   1426       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1476   1730       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1965 AA;  222334 MW;  B854E45AB0CE3E94 CRC64;
     MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGLAASQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYILSPFHPI
     RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV
     WESLDLYLND PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT TCERRSKRRK
     RMSSGTEECG DDRFPKSDSE DGPRAMNRLS ISHGLSRTSM KQRSSRGSIF TFRRRDLGSE
     TDFADDENST AGDSESHRTS LLVPWPLRRP SALGQPSPGT SAPSHALNGK RNSTVDCNGV
     VSLLGAGDPE ATSPGSRLLR PIMLERPPDT TTPSEEPGRP QMLSPQAPCA DGFEEPGERQ
     RALSAVSVLT SVLEELEESH RKCPPCWTRF AQRYLIWECC PLWMSIKQRV KFMVMDPFAD
     LTITLCIVIN TLFMALEHYN MTTEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG
     WNIFDSIIVI LSLMELGLSR MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYSELRY RISDSGLLPR WHMMDFFHAF LIIFRILCGE
     WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT APDEDGEMNN
     LQLALARIQR GLRFVKRTTW DFCCGLLQQR PQKPAALATR DQLPSCIATS GSPQPPETEK
     APPARKETRF EEGNRPGQGT PGDPEPVCVP IAMAESDTDD QEEEEENSLG TEEESSKQTQ
     EDSYSEGSTA DMTNTADLME QIPDLGEDVK DPEDCFTEGC VRRCPCCTVD TTQGPGKVWW
     QLRKTCYRIV EHSWFETFII FMILLSSGAL AFEDIYLEER KTIKVLLEYA DKMFTYVFVL
     EMLLKWVAYG FKKYFTNAWC WLDFLIVDVS LISLVANTLG FAEMGPIKSL RTLRALRPLR
     ALSRFEGMRV VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFGR CINQTEGDLP
     LNYTIVNNKS DCESFNVTGE LYWTKVKVNF DNVGAGYLAL LQVATFKGWM DIMYAAVDSR
     GFEEQPQWEY NLYMYIYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKIRG QDIFMTEEQK
     KYYNAMKKLG SKKPQKPIPR PLNKYQGFLF DIVTKQAFDV TIMFLICLNM VTMMVETDDQ
     SPEKVNILAK INLLFVAIFT GECIIKMTAL RHYYFTNSWN IFDFVVVILS IVGTVLSDII
     QKYFFSPTLF RVIRLARIGR ILRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYS
     IFGMANFAYV KWEAGIDDMF NFQTFANSML CLFQITTSAG WDGLLSPILN TGPPSCDPNL
     PNSNGSRGNC GSPAVGILFF TTYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFD
     MFYEIWEKFD PEATQFIEYS ALSDFADALS EPLRIAKPNQ ISLINMDLPM VSGDRIHCMD
     ILFAFTKRVL GESGEMDALK IQMEEKFMAA NPSKISYEPI TTTLRRKHEE VSATIIQRAF
     RRHLLQRSMK HASFLFRQQA GSSGLSEEDA PEQEGLIAYM MNENFSRRHG PPSSSSISST
     SFPPSYDSVT RATSDNLQAR VSDYSRSEDL ADFPPSPDRD RESIV
//
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