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Database: UniProt
Entry: F6Y4T6_HORSE
LinkDB: F6Y4T6_HORSE
Original site: F6Y4T6_HORSE 
ID   F6Y4T6_HORSE            Unreviewed;      2020 AA.
AC   F6Y4T6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 46.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSECAP00000002630};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002630, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000002630, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002630,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000002630}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002630};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000002630}.
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DR   STRING; 9796.ENSECAP00000002630; -.
DR   PaxDb; F6Y4T6; -.
DR   Ensembl; ENSECAT00000003773; ENSECAP00000002630; ENSECAG00000000813.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F6Y4T6; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002281; Chromosome 16.
DR   Bgee; ENSECAG00000000813; -.
DR   ExpressionAtlas; F6Y4T6; baseline.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    881    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1264       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    945       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1203       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1481       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2020 AA;  228180 MW;  A9108B9B990EA966 CRC64;
     MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGLAASQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYILSPFHPI
     RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV
     WESLDLYLND PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT TCERRSKRRK
     RMSSGTEECG DDRFPKSDSE DGPRAMNRLS ISHGLSRTSM KQRSSRGSIF TFRRRDLGSE
     TDFADDENST AGDSESHRTS LLVPWPLRRP SALGQPSPGT SAPSHALNGK RNSTVDCNGV
     VSLLGAGDPE ATSPGSRLLR PIMLERPPDT TTPSEEPGRP QMLSPQAPCA DGFEEPGERQ
     RALSAVSVLT SVLEELEESH RKCPPCWTRF AQRYLIWECC PLWMSIKQRV KFMVMDPFAD
     LTITLCIVIN TLFMALEHYN MTTEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG
     WNIFDSIIVI LSLMELGLSR MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYSELRY RISDSGLLPR WHMMDFFHAF LIIFRILCGE
     WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT APDEDGEMNN
     LQLALARIQR GLRFVKRTTW DFCCGLLQQR PQKPAALATR DQLPSCIATS GSPQPPETEK
     APPARKETRF EEGNRPGQGT PGDPEPVCVP IAMAESDTDD QEEEEENSLG TEEESSKQQE
     SHPVSGGQEA LPEPRAWSQV SETTSSEAYE ASAAPAERRQ QRQAEPPAPG CSETQEDSYS
     EGSTADMTNT ADLMEQIPDL GEDVKDPEDC FTEGCVRRCP CCTVDTTQGP GKVWWQLRKT
     CYRIVEHSWF ETFIIFMILL SSGALAFEDI YLEERKTIKV LLEYADKMFT YVFVLEMLLK
     WVAYGFKKYF TNAWCWLDFL IVDVSLISLV ANTLGFAEMG PIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFGRCINQT EGDLPLNYTI
     VNNKSDCESF NVTGELYWTK VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRGFEEQ
     PQWEYNLYMY IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKIRGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPLNKY QGFLFDIVTK QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV
     NILAKINLLF VAIFTGECII KMTALRHYYF TNSWNIFDFV VVILSIVGTV LSDIIQKYFF
     SPTLFRVIRL ARIGRILRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA
     NFAYVKWEAG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL SPILNTGPPS CDPNLPNSNG
     SRGNCGSPAV GILFFTTYII ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFDMFYEI
     WEKFDPEATQ FIEYSALSDF ADALSEPLRI AKPNQISLIN MDLPMVSGDR IHCMDILFAF
     TKRVLGESGE MDALKIQMEE KFMAANPSKI SYEPITTTLR RKHEEVSATI IQRAFRRHLL
     QRSMKHASFL FRQQAGSSGL SEEDAPEQEG LIAYMMNENF SRRHGPPSSS SISSTSFPPS
     YDSVTRATSD NLQARVSDYS RSEDLADFPP SPDRDRESIV
//
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